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Camel milk or silymarin could improve the negative effects that experimentally produced by aflatoxin B1 on rat's male reproductive system.
Hassaneen, Nahla H; Hemeda, Shabaan A; El Nahas, Abeer F; Fadl, Sabreen E; El-Diasty, Eman M.
Afiliación
  • Hassaneen NH; Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt. nahlaHamdy@mau.edu.eg.
  • Hemeda SA; Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • El Nahas AF; Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • Fadl SE; Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
  • El-Diasty EM; Mycology Department, Animal Health Research Institute Dokki, Giza (ARC), Egypt.
BMC Vet Res ; 20(1): 108, 2024 Mar 18.
Article en En | MEDLINE | ID: mdl-38500117
ABSTRACT

BACKGROUND:

Camel milk and silymarin have many different beneficial effects on several animal species. Meanwhile, Aflatoxins are mycotoxins with extraordinary potency that pose major health risks to several animal species. Additionally, it has been documented that aflatoxins harm the reproductive systems of a variety of domestic animals. The present design aimed to investigate the impact of aflatoxin B1 (AFB1) on rat body weight and reproductive organs and the ameliorative effects of camel milk and silymarin through measured serum testosterone, testes pathology, and gene expression of tumor necrosis factor (TNF-α), luteinizing hormone receptor (LHR), and steroidogenic acute regulatory protein (StAR) in the testes. A total of sixty mature male Wister white rats, each weighing an average of 83.67 ± 0.21 g, were used. There were six groups created from the rats. Each division had ten rats. The groups were the control (without any treatment), CM (1 ml of camel milk/kg body weight orally), S (20 mg silymarin/kg b. wt. suspension, orally), A (1.4 mg aflatoxin/kg diet), ACM (aflatoxin plus camel milk), and AS (aflatoxin plus silymarin).

RESULTS:

The results indicated the positive effects of camel milk and silymarin on growth, reproductive organs, and gene expression of TNF-α, LHR, and StAR with normal testicular architecture. Also, the negative effect of AFB1 on the rat's body weight and reproductive organs, as indicated by low body weight and testosterone concentration, was confirmed by the results of histopathology and gene expression. However, these negative effects were ameliorated by the ingestion of camel milk and silymarin.

CONCLUSION:

In conclusion, camel milk and silymarin could mitigate the negative effect of AFB1 on rat body weight and reproductive organs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silimarina / Aflatoxinas Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silimarina / Aflatoxinas Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido