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Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study.
Jørgenrud, Benedicte M; Bråthen, Camilla C; Steinson Stenehjem, Jo; Kristiansen, Thomas; Rosseland, Leiv Arne; Bogstrand, Stig Tore.
Afiliación
  • Jørgenrud BM; Section of Drug Abuse Research, Department of Forensic Science, Oslo University Hospital, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway.
  • Bråthen CC; Division of Elverum-Hamar, Department of Acute Medicine, Innlandet Hospital Trust, P.O. Box 104, N-2381 Brumunddal, Norway.
  • Steinson Stenehjem J; Institute of Clinical Medicine, Department of Anesthesia and Intensive Care medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway.
  • Kristiansen T; Institute of Clinical Medicine, Department of Anesthesia and Intensive Care medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway.
  • Rosseland LA; Institute of Clinical Medicine, Department of Anesthesia and Intensive Care medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway.
  • Bogstrand ST; Division of Emergencies and Critical Care, Department of Anaesthesiology, Oslo University Hospital, P.O. Box 4950, N-0424 Oslo, Norway.
Alcohol Alcohol ; 59(3)2024 Mar 16.
Article en En | MEDLINE | ID: mdl-38497164
ABSTRACT

INTRODUCTION:

Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further. Phosphatidylethanol (PEth) 160/181 is a biomarker used to determine alcohol consumption the previous 3-4 weeks. The aim was to investigate the prevalence of chronic alcohol use in trauma patients, as determined by PEth 160/181 concentrations, and how excessive chronic alcohol use relate to demographic variables, injury mechanisms and drug use.

SETTING:

Patients received at Norwegian trauma hospitals from March 2019 to February 2020. The study is part of the Impairing Drugs and Alcohol as Risk factors for Traumatic Injuries study.

METHODS:

All patients aged ≥ 16 years received with trauma team were included in the study. Data on injury date and mechanism, gender and age was registered. Blood samples were analyzed for 22 psychoactive medicinal and illicit drugs, ethanol and phosphatidylethanol 160/181. Regression analyses were conducted to assess associations between alcohol use and gender, age, injury mechanism and drug use. RESULTS AND

CONCLUSION:

Of the 4845 patients included in the study, 10% had PEth 160/181 concentration ≥ 600 nM (~430 ng/mL), indicative of excessive chronic alcohol use. Being male, between 44-61 years old, involved in violence, and testing positive for medicinal drugs was associated with excessive chronic alcohol use.Excessive chronic alcohol use was common among males, middle-aged, patients with violence as injury mechanism and those with medicinal drug use. These findings emphasize the need to detect and treat excessive chronic alcohol use among trauma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Trastornos Relacionados con Sustancias Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Alcohol Alcohol Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Trastornos Relacionados con Sustancias Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Alcohol Alcohol Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido