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Ameliorative effects of propolis and wheat germ oil on acute toxoplasmosis in experimentally infected mice are associated with reduction in parasite burden and restoration of histopathological changes in the brain, uterus, and kidney.
Elmahallawy, Ehab Kotb; Ali, Fatma Abo Zakaib; Raya-Álvarez, Enrique; Fehaid, Alaa; Abd El-Razik, Khaled A; El Fadaly, Hassan Ali Mohamed; El-Khadragy, Manal F; Sayed, Amal S M; Soror, Ashraf H; Alhegaili, Alaa S; Saleh, Amira A; Alkhaldi, Abdulsalam A M; Madboli, Abd El-Nasser A; Agil, Ahmad; Barakat, Ashraf Mohamed.
Afiliación
  • Elmahallawy EK; Departamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain.
  • Ali FAZ; Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.
  • Raya-Álvarez E; Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.
  • Fehaid A; Rheumatology Department, Hospital Universitario San Cecilio, Av. de la Investigación s/n, Granada, Spain.
  • Abd El-Razik KA; Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
  • El Fadaly HAM; Department of Animal Reproduction, Veterinary Research Institute, National Research Centre, Giza, Egypt.
  • El-Khadragy MF; Department of Zoonotic Diseases, National Research Centre, Giza, Egypt.
  • Sayed ASM; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Soror AH; Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt.
  • Alhegaili AS; Department of Animal Reproduction, Veterinary Research Institute, National Research Centre, Giza, Egypt.
  • Saleh AA; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.
  • Alkhaldi AAM; Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Madboli AEA; Biology Department, College of Science, Jouf University, Sakaka, Saudi Arabia.
  • Agil A; Department of Animal Reproduction, Veterinary Research Institute, National Research Centre, Giza, Egypt.
  • Barakat AM; Department of Pharmacology, Biohealth Institute Granada (IBs Granada) and Neuroscience Institute, School of Medicine, University of Granada, Granada, Spain.
Front Vet Sci ; 11: 1357947, 2024.
Article en En | MEDLINE | ID: mdl-38496314
ABSTRACT
Toxoplasmosis continues to be a prevalent parasitic zoonosis with a global distribution. This disease is caused by an intracellular parasite known as Toxoplasma gondii, and the development of effective novel drug targets to combat it is imperative. There is limited information available on the potential advantages of wheat germ oil (WGO) and propolis, both individually and in combination, against the acute phase of toxoplasmosis. In this study, acute toxoplasmosis was induced in Swiss albino mice, followed by the treatment of infected animals with WGO and propolis, either separately or in combination. After 10 days of experimental infection and treatment, mice from all groups were sacrificed, and their brains, uteri, and kidneys were excised for histopathological assessment. Additionally, the average parasite load in the brain was determined through parasitological assessment, and quantification of the parasite was performed using Real-Time Polymerase Chain Reaction targeting gene amplification. Remarkably, the study found that treating infected animals with wheat germ oil and propolis significantly reduced the parasite load compared to the control group that was infected but not treated. Moreover, the group treated with a combination of wheat germ oil and propolis exhibited a markedly greater reduction in parasitic load compared to the other groups. Similarly, the combination treatment effectively restored the histopathological changes observed in the brain, uterus, and kidney, and the scoring of these reported lesions confirmed these findings. In summary, the present results reveal intriguing insights into the potential therapeutic benefits of wheat germ oil and propolis in the treatment of acute toxoplasmosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza