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The Impact of Metagenomics on Biocatalysis.
Hogg, Bethany N; Schnepel, Christian; Finnigan, James D; Charnock, Simon J; Hayes, Martin A; Turner, Nicholas J.
Afiliación
  • Hogg BN; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK.
  • Schnepel C; School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Industrial Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center, 11421, Stockholm, SE.
  • Finnigan JD; Prozomix, Building 4, West End Ind. Estate, Haltwhistle, NE49 9HA, UK.
  • Charnock SJ; Prozomix, Building 4, West End Ind. Estate, Haltwhistle, NE49 9HA, UK.
  • Hayes MA; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D , AstraZeneca, Mölndal 431 50, Gothenburg, SE.
  • Turner NJ; Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK.
Angew Chem Int Ed Engl ; 63(21): e202402316, 2024 05 21.
Article en En | MEDLINE | ID: mdl-38494442
ABSTRACT
In the ever-growing demand for sustainable ways to produce high-value small molecules, biocatalysis has come to the forefront of greener routes to these chemicals. As such, the need to constantly find and optimise suitable biocatalysts for specific transformations has never been greater. Metagenome mining has been shown to rapidly expand the toolkit of promiscuous enzymes needed for new transformations, without requiring protein engineering steps. If protein engineering is needed, the metagenomic candidate can often provide a better starting point for engineering than a previously discovered enzyme on the open database or from literature, for instance. In this review, we highlight where metagenomics has made substantial impact on the area of biocatalysis in recent years. We review the discovery of enzymes in previously unexplored or 'hidden' sequence space, leading to the characterisation of enzymes with enhanced properties that originate from natural selection pressures in native environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biocatálisis / Metagenómica Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biocatálisis / Metagenómica Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Alemania