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Melatonin attenuates fentanyl - induced behavioral sensitization and circadian rhythm disorders in mice.
Du, Kaili; Shi, Qianwen; Zhou, Xiuya; Zhang, Lifei; Su, Hongliang; Zhang, Chao; Wei, Zhiwen; Liu, Ting; Wang, Li; Wang, Xiaohui; Cong, Bin; Yun, Keming.
Afiliación
  • Du K; Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
  • Shi Q; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; Shanxi Key Laboratory of Forensic Medicine, Shanxi, 030600, China.
  • Zhou X; Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China; School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
  • Zhang L; Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China; School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
  • Su H; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; Shanxi Key Laboratory of Forensic Medicine, Shanxi, 030600, China.
  • Zhang C; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; Shanxi Key Laboratory of Forensic Medicine, Shanxi, 030600, China.
  • Wei Z; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; Shanxi Key Laboratory of Forensic Medicine, Shanxi, 030600, China.
  • Liu T; Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China; School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
  • Wang L; Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China; School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
  • Wang X; Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China; School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
  • Cong B; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; Shanxi Key Laboratory of Forensic Medicine, Shanxi, 030600, China; School of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, China.
  • Yun K; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China; Shanxi Key Laboratory of Forensic Medicine, Shanxi, 030600, China. Electronic address: yunkeming5142@163.com.
Physiol Behav ; 279: 114523, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38492912
ABSTRACT
Melatonin is a neurohormone synthesized by the pineal gland to regulate the circadian rhythms and has proven to be effective in treating drug addiction and dependence. However, the effects of melatonin to modulate the drug-seeking behavior of fentanyl and its underlying molecular mechanism is elusive. This study was designed to investigate the effects of melatonin on fentanyl - induced behavioral sensitization and circadian rhythm disorders in mice. The accompanying changes in the expression of Brain and Muscle Arnt-Like (BMAL1), tyrosine hydroxylase (TH), and monoamine oxidase A (MAO-A) in relevant brain regions including the suprachiasmatic nucleus (SCN), nucleus accumbens (NAc), prefrontal cortex (PFC), and hippocampus (Hip) were investigated by western blot assays to dissect the mechanism by which melatonin modulates fentanyl - induced behavioral sensitization and circadian rhythm disorders. The present study suggest that fentanyl (0.05, 0.1 and 0.2 mg/kg) could induce behavioral sensitization and melatonin (30.0 mg/kg) could attenuate the behavioral sensitization and circadian rhythm disorders in mice. Fentanyl treatment reduced the expression of BMAL1 and MAO-A and increased that of TH in relevant brain regions. Furthermore, melatonin treatment could reverse the expression levels of BMAL1, MAO-A, and TH. In conclusion, our study demonstrate for the first time that melatonin has therapeutic potential for fentanyl addiction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Cronobiológicos / Melatonina Límite: Animals Idioma: En Revista: Physiol Behav Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Cronobiológicos / Melatonina Límite: Animals Idioma: En Revista: Physiol Behav Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos