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Sonic hedgehog signalling pathway contributes in age-related disorders and Alzheimer's disease.
Parashar, Arun; Jha, Dhruv; Mehta, Vineet; Chauhan, Bonney; Ghosh, Pappu; Deb, Prashanta Kumar; Jaiswal, Mohit; Prajapati, Santosh Kumar.
Afiliación
  • Parashar A; School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173 212, India. Electronic address: arunnittyparashar@gmail.com.
  • Jha D; Birla Institute of Technology, India.
  • Mehta V; Department of Pharmacology, Government College of Pharmacy, Rohru, District Shimla, Himachal Pradesh 171207, India.
  • Chauhan B; School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173 212, India.
  • Ghosh P; School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173 212, India.
  • Deb PK; School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173 212, India.
  • Jaiswal M; University of Florida, Gainsville, FL, USA.
  • Prajapati SK; Bhavdiya Institute of Pharmaceutical Sciences and Research, Ayodhya, UP, India. Electronic address: Santosh.kumar.phe12@itbhu.ac.in.
Ageing Res Rev ; 96: 102271, 2024 04.
Article en En | MEDLINE | ID: mdl-38492808
ABSTRACT
Alzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway results in neurodegeneration. Several protein-protein interactions that are involved in Shh signalling are implicated in the pathophysiology of AD like overexpression of the protein nexin-1 inhibits the Shh pathway in AD. A protein called Growth Arrest Specific-1 works with another protein called cysteine dioxygenase (CDO) to boost Shh signalling. CDO is involved in the development of the central nervous system (CNS). Shh signalling strengthened the blood brain barrier and therefore prevent the entry of amyloid beta and other toxins to the brain from periphery. Further, several traditional remedies used for AD and dementia, including Epigallocatechin gallate, yokukansan, Lycium barbarum polysaccharides, salvianolic acid, and baicalin, are known to stimulate the Shh pathway. In this review, we elaborated that the Shh signalling exerts a substantial influence on the pathogenesis of AD. In this article, we have tried to explore the various possible connections between the Shh signalling and various known pathologies of AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Hedgehog / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Hedgehog / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido