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Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons.
Wilcox, Natalie C; Taheri, Golnar; Halievski, Katherine; Talbot, Sebastien; Silva, Jaqueline R; Ghasemlou, Nader.
Afiliación
  • Wilcox NC; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
  • Taheri G; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
  • Halievski K; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
  • Talbot S; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
  • Silva JR; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
  • Ghasemlou N; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada. Electronic address:
J Allergy Clin Immunol ; 154(1): 11-19, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38492673
ABSTRACT
Various immune cells in the skin contribute to its function as a first line of defense against infection and disease, and the skin's dense innervation by pain-sensing sensory neurons protects the host against injury or damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis. Langerhans cells (LCs) are a DC subset located only in the epidermis; both populations of cells can migrate to lymph nodes to contribute to broad immune responses. Dermal DCs and LCs are found in close apposition with sensory nerve fibers in the skin and express neurotransmitter receptors, allowing them to communicate directly with the peripheral nervous system. Thus, neuroimmune signaling between DCs and/or LCs and sensory neurons can modulate physiologic and pathophysiologic pathways, including immune cell regulation, host defense, allergic response, homeostasis, and wound repair. Here, we summarize the latest discoveries on DC- and LC-neuron interaction with neurons while providing an overview of gaps and areas not previously explored. Understanding the interactions between these 2 defence systems may provide key insight into developing therapeutic targets for treating diseases such as psoriasis, neuropathic pain, and lupus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Células Dendríticas / Células de Langerhans Límite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Células Dendríticas / Células de Langerhans Límite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos