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Innovative non-targeted screening approach using High-resolution mass spectrometry for the screening of organic chemicals and identification of specific tracers of soil and dust exposure in children.
Ogunbiyi, Olutobi Daniel; Cappelini, Luciana Teresa Dias; Monem, Mymuna; Mejias, Emily; George, Florence; Gardinali, Piero; Bagner, Daniel M; Quinete, Natalia.
Afiliación
  • Ogunbiyi OD; Instittute of Environment, Florida International University, Miami, FL, USA; Department of Chemistry and Biochemistry, Florida International University, 3000 NE 151ST St, Biscayne Bay Campus, Marine Science Building, North Miami, FL 33181, USA.
  • Cappelini LTD; Instittute of Environment, Florida International University, Miami, FL, USA.
  • Monem M; Dept. of Mathematics & Statistics, Florida International University, Miami, FL, USA.
  • Mejias E; Instittute of Environment, Florida International University, Miami, FL, USA; Center for Children and Families, Florida International University, Miami, FL, USA.
  • George F; Dept. of Mathematics & Statistics, Florida International University, Miami, FL, USA.
  • Gardinali P; Instittute of Environment, Florida International University, Miami, FL, USA; Department of Chemistry and Biochemistry, Florida International University, 3000 NE 151ST St, Biscayne Bay Campus, Marine Science Building, North Miami, FL 33181, USA.
  • Bagner DM; Center for Children and Families, Florida International University, Miami, FL, USA; Department of Phycology, Florida International University, Miami, FL, USA.
  • Quinete N; Instittute of Environment, Florida International University, Miami, FL, USA; Department of Chemistry and Biochemistry, Florida International University, 3000 NE 151ST St, Biscayne Bay Campus, Marine Science Building, North Miami, FL 33181, USA. Electronic address: nsoaresq@fiu.edu.
J Hazard Mater ; 469: 134025, 2024 May 05.
Article en En | MEDLINE | ID: mdl-38492398
ABSTRACT
Environmental contamination through direct contact, ingestion and inhalation are common routes of children's exposure to chemicals, in which through indoor and outdoor activities associated with common hand-to-mouth, touching objects, and behavioral tendencies, children can be susceptible and vulnerable to organic contaminants in the environment. The objectives of this study were the screening and identification of a wide range of organic contaminants in indoor dust, soil, food, drinking water, and urine matrices (N = 439), prioritizing chemicals to assess children's environmental exposure, and selection of unique tracers of soil and dust ingestion in young children by non-targeted analysis (NTA) using Q-Exactive Orbitrap followed data processing by the Compound Discoverer (v3.3, SP2). Chemical features were first prioritized based on their predominant abundance (peak area>500,000), detection frequency (in >50% of the samples), available information on their uses and potential toxicological effects. Specific tracers of soil and dust exposure in children were selected in this study including Tripropyl citrate and 4-Dodecylbenzenesulfonic acid. The criteria for selection of the tracers were based on their higher abundance, detection frequency, unique functional uses, measurable amounts in urine (suitable biomarker), and with information on gastrointestinal absorption, metabolism, and excretion, and were further confirmed by authentic standards. We are proposing for the first time suitable unique tracers for dust ingestion by children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Suelo / Contaminación del Aire Interior Límite: Child / Child, preschool / Humans Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Suelo / Contaminación del Aire Interior Límite: Child / Child, preschool / Humans Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos