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Pregnancy renders anatomical changes in hypothalamic substructures of the human brain that relate to aspects of maternal behavior.
Spalek, Klara; Straathof, Milou; Koyuncu, Lal; Grydeland, Håkon; van der Geest, Anouk; Van't Hof, Sophie R; Crone, Eveline A; Barba-Müller, Erika; Carmona, Susana; Denys, Damiaan; Tamnes, Christian K; Burke, Sarah; Hoekzema, Elseline.
Afiliación
  • Spalek K; Hoekzema Lab, Amsterdam University Medical Center (Amsterdam UMC), location University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Amsterdam, the Netherlands.
  • Straathof M; Hoekzema Lab, Amsterdam University Medical Center (Amsterdam UMC), location University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Amsterdam, the Netherlands.
  • Koyuncu L; Brain and Development Research Center, Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands.
  • Grydeland H; Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Norway.
  • van der Geest A; Brain and Development Research Center, Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands.
  • Van't Hof SR; Hoekzema Lab, Amsterdam University Medical Center (Amsterdam UMC), location University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Amsterdam, the Netherlands.
  • Crone EA; Brain and Development Research Center, Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands.
  • Barba-Müller E; Fundació Sanitària Sant Pere Claver, Barcelona, Spain.
  • Carmona S; Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
  • Denys D; Department of Psychiatry, Amsterdam University Medical Center (Amsterdam UMC), location University of Amsterdam, the Netherlands.
  • Tamnes CK; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Burke S; Brain and Development Research Center, Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands; Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University Medical Center Groningen, University of Groningen, the Netherlands.
  • Hoekzema E; Hoekzema Lab, Amsterdam University Medical Center (Amsterdam UMC), location University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Amsterdam, the Netherlands. Electronic address: e.a.hoekzema@amsterdamumc.nl.
Psychoneuroendocrinology ; 164: 107021, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38492349
ABSTRACT
Animal studies have shown that pregnancy is associated with neural adaptations that promote maternal care. The hypothalamus represents a central structure of the mammalian maternal brain and hormonal priming of specific hypothalamic nuclei plays a key role in the induction and expression of maternal behavior. In humans, we have previously demonstrated that becoming a mother involves changes in grey matter anatomy, primarily in association areas of the cerebral cortex. In the current study, we investigated whether pregnancy renders anatomical changes in the hypothalamus. Using an advanced delineation technique, five hypothalamic substructures were defined in longitudinal MRI scans of 107 women extracted from two prospective pre-conception cohort studies, including 50 women who were scanned before and after pregnancy and 57 nulliparous control women scanned at a similar time interval. We showed that becoming a mother is associated with volume reductions in the anterior-superior, superior tuberal and posterior hypothalamus. In addition, these structural changes related to hormonal levels during pregnancy and specific aspects of self-reported maternal behavior in late pregnancy, including maternal-fetal attachment and nesting behavior. These findings show that pregnancy leads to changes in hypothalamic anatomy and suggest that these contribute to the development of maternal behavior in humans, supporting the conservation of key aspects of maternal brain circuitry and their role in maternal behavior across species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Conducta Materna Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Psychoneuroendocrinology Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Conducta Materna Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Psychoneuroendocrinology Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido