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Assessing the risk of exposure to antimicrobial resistance at public beaches: Genome-based insights into the resistomes, mobilomes and virulomes of beta-lactams resistant Enterobacteriaceae from recreational beaches in Lagos, Nigeria.
Oyelade, Abolade A; Ikhimiukor, Odion O; Nwadike, Blessing I; Fagade, Obasola E; Adelowo, Olawale O.
Afiliación
  • Oyelade AA; New Jersey Department of Health, Public Health and Environmental Laboratories, New Jersey, USA.
  • Ikhimiukor OO; Department of Biological Sciences, University at Albany, State University of New York, New York, USA.
  • Nwadike BI; Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria.
  • Fagade OE; Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria.
  • Adelowo OO; Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria. Electronic address: onomewaleadelowo@yahoo.co.uk.
Int J Hyg Environ Health ; 258: 114347, 2024 May.
Article en En | MEDLINE | ID: mdl-38492327
ABSTRACT
The role of recreational water use in the acquisition and transmission of antimicrobial resistance (AMR) is under-explored in low- and middle-income countries (LMICs). We used whole genome sequence analysis to provide insights into the resistomes, mobilomes and virulomes of 14 beta-lactams resistant Enterobacterales isolated from water and wet-sand at four recreational beaches in Lagos, Nigeria. Carriage of multiple beta-lactamase genes was detected in all isolates except two, including six isolates carrying blaNDM-1. Most detected antibiotic resistance genes (ARGs) were located within a diverse landscape of plasmids, insertion sequences and transposons including the presence of ISKpn14 upstream of blaNDM-1 in a first report in Africa. Virulence genes involved in adhesion and motility as well as secretion systems are particularly abundant in the genomes of the isolates. Our results confirmed the four beaches are contaminated with bacteria carrying clinically relevant ARGs associated with mobile genetic elements (MGE) which could promote the transmission of ARGs at the recreational water-human interface.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-Lactamas / Enterobacteriaceae Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Int J Hyg Environ Health Asunto de la revista: SAUDE AMBIENTAL / SAUDE PUBLICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-Lactamas / Enterobacteriaceae Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Int J Hyg Environ Health Asunto de la revista: SAUDE AMBIENTAL / SAUDE PUBLICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania