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Poly-ϵ-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: an experimental piglet study.
Petersen, Laura Lovisa Køtlum; Dursun, Martin Dennis; Madsen, Gunvor; Le, Dang Quang Svend; Möller, Sören; Qvist, Niels; Ellebæk, Mark Bremholm.
Afiliación
  • Petersen LLK; Research Unit of Surgery, Odense University Hospital, Odense, Denmark.
  • Dursun MD; University of Southern Denmark, Odense, Denmark.
  • Madsen G; Research Unit of Surgery, Odense University Hospital, Odense, Denmark. martindursun@gmail.com.
  • Le DQS; University of Southern Denmark, Odense, Denmark. martindursun@gmail.com.
  • Möller S; Research Unit of Pathology, Odense University Hospital, Odense, Denmark.
  • Qvist N; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Ellebæk MB; Open Patient data Explorative Network, Department of Clinical Research, Odense University Hospital and Research unit OPEN, University of Southern Denmark, Odense, Denmark.
BMC Gastroenterol ; 24(1): 112, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38491416
ABSTRACT

PURPOSE:

Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile strength and improve healing compared to a control in a piglet model.

METHOD:

Twenty weaned female piglets received a stapled rectal anastomosis and were randomised to either reinforcement with PCL scaffold (intervention) or no reinforcement (control). On postoperative day five the anastomosis was subjected to a tensile strength test followed by a histological examination to evaluate the wound healing according to the Verhofstad scoring.

RESULTS:

The tensile strength test showed no significant difference between the two groups, but histological evaluation revealed significant impaired wound healing in the intervention group.

CONCLUSION:

The incorporation of a PCL scaffold into a circular stapled rectal anastomosis did not increase anastomotic tensile strength in piglets and indicated an impaired histologically assessed wound healing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caproatos / Grapado Quirúrgico / Fuga Anastomótica / Lactonas Límite: Animals Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caproatos / Grapado Quirúrgico / Fuga Anastomótica / Lactonas Límite: Animals Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido