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Neuroinvasive virus facilitates viral replication by employing lipid droplets to reduce arachidonic acid-induced ferroptosis.
Zhao, Jianqing; Wang, Qianruo; Liu, Zhenkun; Zhang, Mai; Li, Jinquan; Fu, Zhen F; Zhao, Ling; Zhou, Ming.
Afiliación
  • Zhao J; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Frontiers Science Center for Animal Breeding and S
  • Wang Q; College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University Wuhan, China.
  • Liu Z; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Frontiers Science Center for Animal Breeding and S
  • Zhang M; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Frontiers Science Center for Animal Breeding and S
  • Li J; College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University Wuhan, China.
  • Fu ZF; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Frontiers Science Center for Animal Breeding and S
  • Zhao L; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Frontiers Science Center for Animal Breeding and S
  • Zhou M; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Frontiers Science Center for Animal Breeding and S
J Biol Chem ; 300(4): 107168, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38490434
ABSTRACT
Lipids have been previously implicated in the lifecycle of neuroinvasive viruses. However, the role of lipids in programmed cell death and the relationship between programmed cell death and lipid droplets (LDs) in neuroinvasive virus infection remains unclear. Here, we found that the infection of neuroinvasive virus, such as rabies virus and encephalomyocarditis virus could enhance the LD formation in N2a cells, and decreasing LDs production by targeting diacylglycerol acyltransferase could suppress viral replication. The lipidomics analysis revealed that arachidonic acid (AA) was significantly increased after reducing LD formation by restricting diacylglycerol acyltransferase, and AA was further demonstrated to induce ferroptosis to inhibit neuroinvasive virus replication. Moreover, lipid peroxidation and viral replication inhibition could be significantly alleviated by a ferroptosis inhibitor, ferrostatin-1, indicating that AA affected neuroinvasive virus replication mainly through inducing ferroptosis. Furthermore, AA was demonstrated to activate the acyl-CoA synthetase long-chain family member 4-lysophosphatidylcholine acyltransferase 3-cytochrome P450 oxidoreductase axis to induce ferroptosis. Our findings highlight novel cross-talks among viral infection, LDs, and ferroptosis for the first time, providing a potential target for antiviral drug development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Replicación Viral / Ácido Araquidónico / Gotas Lipídicas / Ferroptosis Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Replicación Viral / Ácido Araquidónico / Gotas Lipídicas / Ferroptosis Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos