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Hypercapnia and its relationship with respiratory infections.
Campaña-Duel, Elena; Ceccato, Adrian; Morales-Quinteros, Luis; Camprubí-Rimblas, Marta; Artigas, Antonio.
Afiliación
  • Campaña-Duel E; Critical care center, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA). Universitat Autònoma de Barcelona, Sabadell, Spain.
  • Ceccato A; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
  • Morales-Quinteros L; Critical care center, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA). Universitat Autònoma de Barcelona, Sabadell, Spain.
  • Camprubí-Rimblas M; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.
  • Artigas A; Intensive care unit, Hospital Universitari Sagrat Cor, Grupo Quironsalud, Barcelona, Spain.
Expert Rev Respir Med ; 18(1-2): 41-47, 2024.
Article en En | MEDLINE | ID: mdl-38489161
ABSTRACT

INTRODUCTION:

Hypercapnia is developed in patients with acute and/or chronic respiratory conditions. Clinical data concerning hypercapnia and respiratory infections interaction is limited. AREAS COVERED Currently, the relationship between hypercapnia and respiratory infections remains unclear. In this review, we summarize studies on the effects of hypercapnia on models of pulmonary infections to clarify the role of elevated CO2 in these pulmonary pathologies. Hypercapnia affects different cell types in the alveoli, leading to changes in the immune response. In vitro studies show that hypercapnia downregulates the NF-κß pathway, reduces inflammation and impairs epithelial wound healing. While in vivo models show a dual role between short- and long-term effects of hypercapnia on lung infection. However, it is still controversial whether the effects observed under hypercapnia are pH dependent or not. EXPERT OPINION The role of hypercapnia is still a controversial debate. Hypercapnia could play a beneficial role in mechanically ventilated models, by lowering the inflammation produced by the stretch condition. But it could be detrimental in infectious scenarios, causing phagocyte dysfunction and lack of infection control. Further data concerning hypercapnia on respiratory infections is needed to elucidate this interaction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Hipercapnia Límite: Humans Idioma: En Revista: Expert Rev Respir Med Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Hipercapnia Límite: Humans Idioma: En Revista: Expert Rev Respir Med Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido