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Psoralen: a narrative review of current and future therapeutic uses.
Galiatsatos, Panagis; Maydan, Daniella D; Macalpine, Elle; Schleupner, Beatrice; Aitchison, Alexandra Hunter; Lerner, Andrew D; Levy, Benjamin; Halthore, Aditya; Eward, William.
Afiliación
  • Galiatsatos P; The Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins School of Medicine, 4940 Eastern Avenue, 4th Floor, Asthma & Allergy Building, Baltimore, MD, 21224, USA. pgaliat1@jhmi.edu.
  • Maydan DD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. pgaliat1@jhmi.edu.
  • Macalpine E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Schleupner B; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.
  • Aitchison AH; Department of Orthopaedic Surgery and Duke Cancer Institute, Duke University, Durham, NC, USA.
  • Lerner AD; Department of Orthopaedic Surgery and Duke Cancer Institute, Duke University, Durham, NC, USA.
  • Levy B; The Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins School of Medicine, 4940 Eastern Avenue, 4th Floor, Asthma & Allergy Building, Baltimore, MD, 21224, USA.
  • Halthore A; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Eward W; The Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins School of Medicine, 4940 Eastern Avenue, 4th Floor, Asthma & Allergy Building, Baltimore, MD, 21224, USA.
J Cancer Res Clin Oncol ; 150(3): 130, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38489072
ABSTRACT
Psoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves. Psoralens penetrate the phospholipid cellular membranes and insert themselves between the pyrimidines of deoxyribonucleic acid (DNA). Psoralens are initially biologically inert and acquire photoreactivity when exposed to certain classes of electromagnetic radiation, such as ultraviolet light. Once activated, psoralens form mono- and di-adducts with DNA, leading to marked cell apoptosis. This apoptotic effect is more pronounced in tumor cells due to their high rate of cell division. Moreover, photoactivated psoralen can inhibit tyrosine kinase signaling and influence the immunogenic properties of cells. Thus, the cytotoxicity of photoactivated psoralen holds promising clinical applications from its immunogenic properties to potential anti-cancer treatments. This narrative review aims to provide an overview of the current understanding and research on psoralen and to explore its potential future pharmacotherapeutic benefits in specific diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furocumarinas / Ficusina Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furocumarinas / Ficusina Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania