Your browser doesn't support javascript.
loading
Light chain deposition disease presenting with gastrointestinal disorder as primary manifestation: report of two cases and literature review.
Wei, Chenxiang; Wang, Min; Li, Jiamin; Su, Jiajun; Huang, Jing; Tong, Sunwing; Yang, Dongye.
Afiliación
  • Wei C; Division of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
  • Wang M; Division of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
  • Li J; Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
  • Su J; Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
  • Huang J; Department of Hematology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
  • Tong S; Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
  • Yang D; Division of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, P.R. China.
J Int Med Res ; 52(3): 3000605241233972, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38488658
ABSTRACT
Light chain deposition disease (LCDD) is an under-recognized condition characterized by deposition of abnormal monoclonal light chains in tissues, leading to organ dysfunction. LCDD involving the gastrointestinal tract is very uncommon, and its diagnosis is challenging. We herein report two cases of LCDD that manifested as inflammatory bowel disease-like symptoms and protein-losing gastroenteropathy. Both patients were women in their early 60s. Tissue biopsies from the gastrointestinal mucosa demonstrated extracellular deposits, which were negative by Congo red staining but positive for κ-light chain by immunohistochemistry. The recent literature on LCDD was reviewed. When patients unexpectedly show extracellular deposits in gastrointestinal biopsy specimens, evaluation of immunoglobulin chains is recommended for diagnosis of LCDD after systemic amyloidosis has been excluded.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Gastrointestinales / Amiloidosis / Mieloma Múltiple Límite: Female / Humans / Male Idioma: En Revista: J Int Med Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Gastrointestinales / Amiloidosis / Mieloma Múltiple Límite: Female / Humans / Male Idioma: En Revista: J Int Med Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido