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Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury.
Wang, Jiawan; Zhang, Hao; Yuan, Hailong; Chen, Siqi; Yu, Ying; Zhang, Xuan; Gao, Zeyu; Du, Heng; Li, Weitao; Wang, Yaohui; Xia, Pengyan; Wang, Jun; Song, Moshi.
Afiliación
  • Wang J; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Zhang H; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Yuan H; Key Laboratory of Organ Regeneration and Reconstruction, Chinese Academy of Sciences, Beijing, 100101, China.
  • Chen S; Beijing Chao-Yang Hospital, Department of Anesthesiology, Beijing, 100020, China.
  • Yu Y; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Zhang X; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Gao Z; Key Laboratory of Organ Regeneration and Reconstruction, Chinese Academy of Sciences, Beijing, 100101, China.
  • Du H; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Li W; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang Y; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Xia P; Key Laboratory of Organ Regeneration and Reconstruction, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang J; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, 475004, China.
  • Song M; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Adv Sci (Weinh) ; 11(18): e2307233, 2024 May.
Article en En | MEDLINE | ID: mdl-38487926
ABSTRACT
The gut microbiome has emerged as a potential target for the treatment of cardiovascular disease. Ischemia/reperfusion (I/R) after myocardial infarction is a serious complication and whether certain gut bacteria can serve as a treatment option remains unclear. Lactobacillus reuteri (L. reuteri) is a well-studied probiotic that can colonize mammals including humans with known cholesterol-lowering properties and anti-inflammatory effects. Here, the prophylactic cardioprotective effects of L. reuteri or its metabolite γ-aminobutyric acid (GABA) against acute ischemic cardiac injury caused by I/R surgery are demonstrated. The prophylactic gavage of L. reuteri or GABA confers cardioprotection mainly by suppressing cardiac inflammation upon I/R. Mechanistically, GABA gavage results in a decreased number of proinflammatory macrophages in I/R hearts and GABA gavage no longer confers any cardioprotection in I/R hearts upon the clearance of macrophages. In vitro studies with LPS-stimulated bone marrow-derived macrophages (BMDM) further reveal that GABA inhibits the polarization of macrophages toward the proinflammatory M1 phenotype by inhibiting lysosomal leakage and NLRP3 inflammasome activation. Together, this study demonstrates that the prophylactic oral administration of L. reuteri or its metabolite GABA attenuates macrophage-mediated cardiac inflammation and therefore alleviates cardiac dysfunction after I/R, thus providing a new prophylactic strategy to mitigate acute ischemic cardiac injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Modelos Animales de Enfermedad / Limosilactobacillus reuteri / Ácido gamma-Aminobutírico / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Modelos Animales de Enfermedad / Limosilactobacillus reuteri / Ácido gamma-Aminobutírico / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania