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The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies.
Wang, Shuo; Liu, Tian; Huang, Yuetong; Du, Chaoying; Wang, Danping; Wang, Xiyan; Lv, Qingzhi; He, Zhonggui; Zhai, Yinglei; Sun, Bingjun; Sun, Jin.
Afiliación
  • Wang S; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Liu T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Huang Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Du C; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang D; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Lv Q; School of Pharmacy, Binzhou Medical University, Binzhou 256600, China.
  • He Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zhai Y; School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Sun B; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Sun J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Acta Pharm Sin B ; 14(3): 1400-1411, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38486988
ABSTRACT
The self-assembly prodrugs are usually consisted of drug modules, activation modules, and assembly modules. Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug nanoassemblies. This study designed four docetaxel (DTX) prodrugs using disulfide bonds as activation modules and different lengths of branched-chain fatty alcohols as assembly modules (C16, C18, C20, and C24). The lengths of the assembly modules determined the self-assembly ability of prodrugs and affected the activation modules' sensitivity. The extension of the carbon chains improved the prodrugs' self-assembly ability and pharmacokinetic behavior while reducing the cytotoxicity and increased cumulative toxicity. The use of C20 can balance efficacy and safety. These results provide a great reference for the rational design of prodrug nanoassemblies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos