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The clinical impact of mRNA therapeutics in the treatment of cancers, infections, genetic disorders, and autoimmune diseases.
Deyhimfar, Roham; Izady, Mehrnaz; Shoghi, Mohammadreza; Kazazi, Mohammad Hossein; Ghazvini, Zahra Fakhraei; Nazari, Hojjatollah; Fekrirad, Zahra; Arefian, Ehsan.
Afiliación
  • Deyhimfar R; Department of Stem Cells Technology and Tissue Regeneration, School of Biology, College of Science, University of Tehran, Tehran, Iran.
  • Izady M; Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Shoghi M; Department of Stem Cells Technology and Tissue Regeneration, School of Biology, College of Science, University of Tehran, Tehran, Iran.
  • Kazazi MH; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Ghazvini ZF; Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, ON, Canada.
  • Nazari H; Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
  • Fekrirad Z; School of Biomedical Engineering, University of Technology Sydney, Sydney, Australia.
  • Arefian E; Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran.
Heliyon ; 10(5): e26971, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38486748
ABSTRACT
mRNA-based therapeutics have revolutionized medicine and the pharmaceutical industry. The recent progress in the optimization and formulation of mRNAs has led to the development of a new therapeutic platform with a broad range of applications. With a growing body of evidence supporting the use of mRNA-based drugs for precision medicine and personalized treatments, including cancer immunotherapy, genetic disorders, and autoimmune diseases, this emerging technology offers a rapidly expanding category of therapeutic options. Furthermore, the development and deployment of mRNA vaccines have facilitated a prompt and flexible response to medical emergencies, exemplified by the COVID-19 outbreak. The establishment of stable and safe mRNA molecules carried by efficient delivery systems is now available through recent advances in molecular biology and nanotechnology. This review aims to elucidate the advancements in the clinical applications of mRNAs for addressing significant health-related challenges such as cancer, autoimmune diseases, genetic disorders, and infections and provide insights into the efficacy and safety of mRNA therapeutics in recent clinical trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido