Your browser doesn't support javascript.
loading
Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization.
Ummat, Viruja; Sivagnanam, Saravana Periaswamy; Rai, Dilip K; O'Donnell, Colm; Conway, Gillian E; Heffernan, Shane M; Fitzpatrick, Stephen; Lyons, Henry; Curtin, James; Tiwari, Brijesh Kumar.
Afiliación
  • Ummat V; Teagasc Ashtown Food Research Centre, Teagasc, Ashtown, Dublin 15, Ireland. viruja.ummat@teagasc.ie.
  • Sivagnanam SP; UCD School of Biosystems and Food Engineering, University College Dublin, Belfield, Dublin 4, Ireland. viruja.ummat@teagasc.ie.
  • Rai DK; BiOrbic Bioeconomy SFI Research Centre, University College Dublin, Belfield, Dublin 4, Ireland. viruja.ummat@teagasc.ie.
  • O'Donnell C; Department of Biological Sciences, Munster Technological University, Bishopstown, T12P928, Cork, Ireland.
  • Conway GE; Teagasc Ashtown Food Research Centre, Teagasc, Ashtown, Dublin 15, Ireland.
  • Heffernan SM; UCD School of Biosystems and Food Engineering, University College Dublin, Belfield, Dublin 4, Ireland.
  • Fitzpatrick S; In Vitro Toxicology Group, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, SA3 5AU, UK.
  • Lyons H; Applied Sports Science Technology and Medicine Research Centre (A-STEM), Faculty of Science and Engineering, Swansea University, Swansea, Wales, SA3 5AU, UK.
  • Curtin J; Nutramara Ltd., Beechgrove House Strand Street, Tralee, Ireland.
  • Tiwari BK; Nutramara Ltd., Beechgrove House Strand Street, Tralee, Ireland.
Sci Rep ; 14(1): 6214, 2024 03 14.
Article en En | MEDLINE | ID: mdl-38486008
ABSTRACT
Fucoidan has attracted considerable attention from scientists and pharmaceutical companies due to its antioxidant, anticoagulant, anti-inflammatory, anti-tumor, and health-enhancing properties. However, the extraction of fucoidan from seaweeds often involves the use of harsh chemicals, which necessitates the search for alternative solvents. Additionally, the high viscosity and low cell permeability of high molecular weight (Mw) fucoidan can limit its effectiveness in drug action, while lower Mw fractions exhibit increased biological activity and are also utilized as dietary supplements. The study aimed to (1) extract fucoidan from the seaweed Fucus vesiculosus (FV) using an environmentally friendly solvent and compare it with the most commonly used extraction solvent, hydrochloric acid, and (2) assess the impact of ultrasound-assisted depolymerization on reducing the molecular weight of the fucoidan extracts and examine the cytotoxic effect of different molecular weight fractions. The findings indicated that the green depolymerization solvent, in conjunction with a brief ultrasound treatment, effectively reduced the molecular weight. Moreover, a significant decrease in cell viability was observed in selected samples, indicating potential anticancer properties. As a result, ultrasound was determined to be an effective method for depolymerizing crude fucoidan from Fucus Vesiculosus seaweed.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Algas Marinas / Fucus Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Algas Marinas / Fucus Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido