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Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure.
Danielsen, Pernille Høgh; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Clausen, Per Axel; Jensen, Keld Alstrup; Wallin, Håkan; Vogel, Ulla.
Afiliación
  • Danielsen PH; National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark.
  • Poulsen SS; National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark.
  • Knudsen KB; National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark.
  • Clausen PA; National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark.
  • Jensen KA; National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark.
  • Wallin H; National Institute of Occupational Health, Pb 5330 Majorstuen, Oslo 0304, Norway; Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, Copenhagen K DK-1014, Denmark.
  • Vogel U; National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark; DTU Food, Technical University of Denmark (DTU), Anker Engelunds Vej 1, Lyngby DK-2800 Kgs, Denmark. Electronic address: ubv@nfa.dk.
Environ Toxicol Pharmacol ; 107: 104413, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38485102
ABSTRACT
Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter and SWCNT specific surface area were predictive of lower and higher neutrophil influx, respectively. Manganese and iron were shown to be predictive of higher neutrophil influx at day 1 post-exposure, whereas nickel content interestingly was predictive of lower neutrophil influx at all three time points and of lowered acute phase response at day 1 and 3 months post-exposure. It was not possible to separate effects of properties such as specific surface area and length in the multiple regression analyses due to co-variation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Nanotubos de Carbono Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Nanotubos de Carbono Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos