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A comprehensive investigation on the receptor BSG expression reveals the potential risk of healthy individuals and cancer patients to 2019-nCoV infection.
Huang, Yongbiao; Zhou, Haiting; Wang, Yuan; Xiao, Lingyan; Qin, Wan; Li, Long.
Afiliación
  • Huang Y; Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Zhou H; Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Wang Y; Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Xiao L; Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Qin W; Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Li L; Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Aging (Albany NY) ; 16(6): 5412-5434, 2024 03 13.
Article en En | MEDLINE | ID: mdl-38484369
ABSTRACT

BACKGROUND:

Coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerging coronavirus. BSG (basigin) is involved in the tumorigenesis of multiple tumors and recently emerged as a novel viral entry receptor for SARS-CoV-2. However, its expression profile in normal individuals and cancer patients are still unclear.

METHODS:

We performed a comprehensive analysis of the expression and distribution of BSG in normal tissues, tumor tissues, and cell lines via bioinformatics analysis and experimental verification. In addition, we investigated the expression of BSG and its isoforms in multiple malignancies and adjacent normal tissues, and explored the prognostic values across pan-cancers. Finally, we conducted function analysis for co-expressed genes with BSG.

RESULTS:

We found BSG was highly conserved in different species, and was ubiquitously expressed in almost all normal tissues and significantly increased in some types of cancer tissues. Moreover, BSG at mRNA expression level was higher than ACE2 in normal lung tissues, and lung cancer tissues. High expression of BSG indicated shorter overall survival (OS) in multiple tumors. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that BSG is mostly enriched in genes for mitochondria electron transport, oxidoreduction-driven active transmembrane transporter activity, mitochondrial inner membrane, oxidative phosphorylation, and genes involving COVID-19.

CONCLUSIONS:

Our present work emphasized the value of targeting BSG in the treatment of COVID-19 and cancer, and also provided several novel insights for understanding the SARS-CoV-2 pandemic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos