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Widespread White Matter Abnormalities in Concussed Athletes Detected by 7T Diffusion Magnetic Resonance Imaging.
Gard, Anna; Kornaropoulos, Evgenios N; Portonova Wernersson, Maria; Rorsman, Ia; Blennow, Kaj; Zetterberg, Henrik; Tegner, Yelverton; De Maio, Alessandro; Markenroth Bloch, Karin; Björkman-Burtscher, Isabella; Pessah-Rasmussen, Hélène; Nilsson, Markus; Marklund, Niklas.
Afiliación
  • Gard A; Department of Clinical Sciences Lund, Neurosurgery, Neurology, Lund University, Lund, Sweden.
  • Kornaropoulos EN; Department of Clinical Sciences Lund, Diagnostic Radiology, Neurology, Lund University, Lund, Sweden.
  • Portonova Wernersson M; Department of Neurology, Rehabilitation Medicine, Memory Disorders and Geriatrics, Skåne University Hospital, Neurology, Lund University, Lund, Sweden.
  • Rorsman I; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
  • Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Tegner Y; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  • De Maio A; UK Dementia Research Institute at UCL, London, UK.
  • Markenroth Bloch K; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.
  • Björkman-Burtscher I; Department of Health, Education and Technology, Division of Health and Rehabilitation, Luleå University of Technology, Luleå, Sweden.
  • Pessah-Rasmussen H; Department of Radiological, Oncological and Pathological Sciences. Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
  • Nilsson M; Department of Clinical Sciences Lund, Lund University Bioimaging Center, Lund University, Lund, Sweden.
  • Marklund N; Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
J Neurotrauma ; 41(13-14): 1533-1549, 2024 07.
Article en En | MEDLINE | ID: mdl-38481124
ABSTRACT
Sports-related concussions may cause white matter injuries and persistent post-concussive symptoms (PPCS). We hypothesized that athletes with PPCS would have neurocognitive impairments and white matter abnormalities that could be revealed by advanced neuroimaging using ultra-high field strength diffusion tensor (DTI) and diffusion kurtosis (DKI) imaging metrics and cerebrospinal fluid (CSF) biomarkers. A cohort of athletes with PPCS severity limiting the ability to work/study and participate in sport school and/or social activities for ≥6 months completed 7T magnetic resonance imaging (MRI) (morphological T1-weighed volumetry, DTI and DKI), extensive neuropsychological testing, symptom rating, and CSF biomarker sampling. Twenty-two athletes with PPCS and 22 controls were included. Concussed athletes performed below norms and significantly lower than controls on all but one of the psychometric neuropsychology tests. Supratentorial white and gray matter, as well as hippocampal volumes did not differ between concussed athletes and controls. However, of the 72 examined white matter tracts, 16% of DTI and 35% of DKI metrics (in total 28%) were significantly different between concussed athletes and controls. DKI fractional anisotropy and axial kurtosis were increased, and DKI radial diffusivity and radial kurtosis decreased in concussed athletes when compared with controls. CSF neurofilament light (NfL; an axonal injury marker), although not glial fibrillary acidic protein, correlated with several diffusion metrics. In this first 7T DTI and DKI study investigating PPCS, widespread microstructural alterations were observed in the white matter, correlating with CSF markers of axonal injury. More white matter changes were observed using DKI than using DTI. These white matter alterations may indicate persistent pathophysiological processes following concussion in sport.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos en Atletas / Conmoción Encefálica / Atletas / Sustancia Blanca Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Neurotrauma Asunto de la revista: NEUROLOGIA / TRAUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos en Atletas / Conmoción Encefálica / Atletas / Sustancia Blanca Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Neurotrauma Asunto de la revista: NEUROLOGIA / TRAUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos