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Impact of 25-hydroxy vitamin D levels in severe acute respiratory syndrome coronavirus 2 patients with respect to clinical and biochemical profile: An experience from a tertiary care hospital.
Valapala, Venkat Narayana Goutham; Dasari, Nikhila; Kolli, Viswa Kalyan; Mandapaka, Murty.
Afiliación
  • Valapala VNG; Department of General Medicine, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University), Visakhapatnam, 530045, India.
  • Dasari N; Department Of Respiratory Medicine, GITAM Institute of Medical Sciences and Research, GITAM (Deemed To Be University), Visakhapatnam, 530045, India.
  • Kolli VK; Department of Biochemistry, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University), Visakhapatnam, 530045, India. Electronic address: kolli.kalyan@gmail.com.
  • Mandapaka M; Department of General Medicine, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University), Visakhapatnam, 530045, India.
Clin Nutr ESPEN ; 60: 187-194, 2024 04.
Article en En | MEDLINE | ID: mdl-38479909
ABSTRACT

INTRODUCTION:

Among the many micronutrients, Vitamin D deficiency has been associated with the severity of Severe Acute Respiratory Syndrome Coronavirus 2 patients. DESIGN AND

METHODS:

A retrospective observational study was conducted on Severe acute respiratory syndrome coronavirus 2 patients admitted to a tertiary care hospital between April 5, 2021, and May 5, 2021.

RESULTS:

Among 285 patients,77.2 % of the patients who stayed for more than 14 days were either Vitamin D insufficient or deficient [P value < 0.05]. In our study, the mean oxygen saturation at admission was 85.7 % in the Vitamin D deficiency group compared to 95.6 % in Vitamin D sufficiency patients [P value < 0.05]. Mean serum ferritin was 398 ng/ml in the Vitamin D deficiency group compared to 393 ng/ml in Vitamin D sufficiency patients [P value > 0.05]. The mean C-reactive protein was 107.6 mg/ml in the Vitamin D deficiency group compared to 21.8 ng/ml in Vitamin D sufficiency patients [P value < 0.05]. The mean D-Dimer was 2268 ng/ml in the Vitamin D deficiency group compared to 781 ng/ml in Vitamin D sufficiency patients [P value < 0.05]. In the non-survivor group,97.4 % were Vitamin D deficient and insufficient. Only 2 % of the patients who survived were Vitamin D deficient [P value < 0.05].

CONCLUSION:

We observed that low 25-hydroxy Vitamin D levels were associated with lower oxygen saturation and higher acute physiology and chronic health evaluation II scores, requiring a more extended stay in the hospital. C-reactive protein and D-dimers were significantly higher in Vitamin D deficient patients, suggesting severe disease. We did not find statistically significant findings in the case of the correlation of serum ferritin levels with Vitamin D status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / COVID-19 Límite: Humans Idioma: En Revista: Clin Nutr ESPEN Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / COVID-19 Límite: Humans Idioma: En Revista: Clin Nutr ESPEN Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido