Your browser doesn't support javascript.
loading
A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer.
Han, Pei-Zhen; Ye, Wei-Dong; Yu, Peng-Cheng; Tan, Li-Cheng; Shi, Xiao; Chen, Xu-Feng; He, Cong; Hu, Jia-Qian; Wei, Wen-Jun; Lu, Zhong-Wu; Qu, Ning; Wang, Yu; Ji, Qing-Hai; Ji, Dong-Mei; Wang, Yu-Long.
Afiliación
  • Han PZ; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Ye WD; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Yu PC; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Tan LC; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Shi X; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Chen XF; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • He C; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China.
  • Hu JQ; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Wei WJ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Lu ZW; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Qu N; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang Y; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Ji QH; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Ji DM; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang YL; Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
JCI Insight ; 9(8)2024 Mar 07.
Article en En | MEDLINE | ID: mdl-38478516
ABSTRACT
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows resistance to conventional therapies. However, clinical trials found that immunotherapy works better in ATC than late-stage PTC. Here, we used single-cell RNA sequencing (scRNA-Seq) to generate a single-cell atlas of thyroid cancer. Differences in ATC and PTC tumor microenvironment components (including malignant cells, stromal cells, and immune cells) leading to the polarized prognoses were identified. Intriguingly, we found that CXCL13+ T lymphocytes were enriched in ATC samples and might promote the development of early tertiary lymphoid structure (TLS). Last, murine experiments and scRNA-Seq analysis of a treated patient's tumor demonstrated that famitinib plus anti-PD-1 antibody could advance TLS in thyroid cancer. We displayed the cellular landscape of ATC and PTC, finding that CXCL13+ T cells and early TLS might make ATC more sensitive to immunotherapy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Quimiocina CXCL13 / Microambiente Tumoral / Carcinoma Anaplásico de Tiroides / Cáncer Papilar Tiroideo / Inmunoterapia Límite: Animals / Female / Humans / Male Idioma: En Revista: JCI Insight Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Quimiocina CXCL13 / Microambiente Tumoral / Carcinoma Anaplásico de Tiroides / Cáncer Papilar Tiroideo / Inmunoterapia Límite: Animals / Female / Humans / Male Idioma: En Revista: JCI Insight Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos