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Mesenchymal Stem Cells-Involved Strategies for Rheumatoid Arthritis Therapy.
Li, Chaoyang; Sun, Yifu; Xu, Weiguo; Chang, Fei; Wang, Yinan; Ding, Jianxun.
Afiliación
  • Li C; Department of Orthopedics, The Second Hospital of Jilin University, 4026 Yatai Street, Changchun, 130041, P. R. China.
  • Sun Y; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, P. R. China.
  • Xu W; Department of Orthopedics, The Second Hospital of Jilin University, 4026 Yatai Street, Changchun, 130041, P. R. China.
  • Chang F; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, P. R. China.
  • Wang Y; Department of Orthopedics, The Second Hospital of Jilin University, 4026 Yatai Street, Changchun, 130041, P. R. China.
  • Ding J; Department of Biobank, Division of Clinical Research, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, P. R. China.
Adv Sci (Weinh) ; 11(24): e2305116, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38477559
ABSTRACT
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints and bone destruction. Because of systemic administration and poor targeting, traditional anti-rheumatic drugs have unsatisfactory treatment efficacy and strong side effects, including myelosuppression, liver or kidney function damage, and malignant tumors. Consequently, mesenchymal stem cells (MSCs)-involved therapy is proposed for RA therapy as a benefit of their immunosuppressive and tissue-repairing effects. This review summarizes the progress of MSCs-involved RA therapy through suppressing inflammation and promoting tissue regeneration and predicts their potential clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article Pais de publicación: Alemania