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Injectable Chitosan Hydrogels Doped with 2D Peptide Nanosheet-Drug Conjugates for Glutathione-Responsive Sustained Drug Delivery.
Luan, Xin; Hu, Huiqiang; Zhu, Danzhu; He, Peng; Sun, Zhengang; Xi, Yongming; Wei, Gang.
Afiliación
  • Luan X; College of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, PR China.
  • Hu H; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266035, PR China.
  • Zhu D; College of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, PR China.
  • He P; College of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, PR China.
  • Sun Z; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266035, PR China.
  • Xi Y; Department of Spinal Surgery, Qingdao Huangdao Central Hospital, Qingdao University Medical Group, Qingdao, 266555, PR China.
  • Wei G; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266035, PR China.
Chemistry ; 30(28): e202400021, 2024 May 17.
Article en En | MEDLINE | ID: mdl-38477386
ABSTRACT
The development of novel and effective drug delivery systems aimed at enhancing therapeutic profile and efficacy of therapeutic agents is a critical challenge in modern medicine. This study presents an intelligent drug delivery system based on self-assembled two-dimensional peptide nanosheets (2D PNSs). Leveraging the tunable properties of amino acid structures and sequences, we design a peptide with the sequence of Fmoc-FKKGSHC, which self-assembles into 2D PNSs with uniform structure, high biocompatibility, and excellent degradability. Covalent attachment of thiol-modified doxorubicin (DOX) drugs to 2D PNSs via disulfide bond results in the peptide-drug conjugates (PDCs), which is denoted as PNS-SS-DOX. Subsequently, the PDCs are encapsulated within the injectable, thermosensitive chitosan (CS) hydrogels for drug delivery. The designed drug delivery system demonstrates outstanding pH-responsiveness and sustained drug release capabilities, which are facilitated by the characteristics of the CS hydrogels. Meanwhile, the covalently linked disulfide bond within the PNS-SS-DOX is responsive to intracellular glutathione (GSH) within tumor cells, enabling controlled drug release and significantly inhibiting the cancer cell growth. This responsive peptide-drug conjugate based on a 2D peptide nanoplatform paves the way for the development of smart drug delivery systems and has bright prospects in the future biomedicine field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Doxorrubicina / Hidrogeles / Quitosano / Nanoestructuras / Liberación de Fármacos / Glutatión Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Doxorrubicina / Hidrogeles / Quitosano / Nanoestructuras / Liberación de Fármacos / Glutatión Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania