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Easy but Efficient: Facile Approach to Molecule with Theoretically Justified Donor-Acceptor Structure for Effective Photothermal Conversion and Intravenous Photothermal Therapy.
Zhong, Yuan-Hui; Huang, Gui-Feng; Zhao, Sheng-Yi; Chung, Lai-Hon; Zhang, Hua-Tang; Zheng, Jin-Hong; Yan, Yi-Lang; Ni, Wen-Xiu; He, Jun.
Afiliación
  • Zhong YH; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
  • Huang GF; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.
  • Zhao SY; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
  • Chung LH; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
  • Zhang HT; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
  • Zheng JH; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.
  • Yan YL; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.
  • Ni WX; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.
  • He J; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
Adv Sci (Weinh) ; 11(24): e2309068, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38477060
ABSTRACT
To accelerate the pace in the field of photothermal therapy (PTT), it is urged to develop easily accessible photothermal agents (PTAs) showing high photothermal conversion efficiency (PCE). As a proof-of-concept, hereby a conventional strategy is presented to prepare donor-acceptor (D-A) structured PTAs through cycloaddition-retroelectrocyclization (CA-RE) reaction, and the resultant PTAs give high PCE upon near-infrared (NIR) irradiation. By joint experimental-theoretical study, these PTAs exhibit prominent D-A structure with strong intramolecular charge transfer (ICT) characteristics and significantly twisting between D and A units which account for the high PCEs. Among them, the DMA-TCNQ exhibits the strongest absorption in NIR range as well as the highest PCE of 91.3% upon irradiation by 760-nm LED lamp (1.2 W cm-2). In vitro and in vivo experimental results revealed that DMA-TCNQ exhibits low dark toxicity and high phototoxicity after IR irradiation along with nude mice tumor inhibition up to 81.0% through intravenous therapy. The findings demonstrate CA-RE reaction as a convenient approach to obtain twisted D-A structured PTAs for effective PTT and probably promote the progress of cancer therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Fototérmica / Ratones Desnudos Límite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Fototérmica / Ratones Desnudos Límite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article Pais de publicación: Alemania