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Cerumenolytic Effects of Carbamide Peroxide in Patients with Ear Wax Obstruction.
Asgari, Alireza; Asgari, Hamid Reza; Ghorbanlou, Mehrdad; Dobakhti, Faramarz; Ghorbanian, Mohammad Ali.
Afiliación
  • Asgari A; Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Asgari HR; Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Ghorbanlou M; Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Dobakhti F; Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Ghorbanian MA; Department of Otolaryngology, Valiasr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran .
Iran J Otorhinolaryngol ; 36(2): 415-420, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38476567
ABSTRACT

Introduction:

Accumulated and compacted ear wax or cerumen can cause conductive hearing loss, discomfort and vertigo, and infection. This study investigates the effect of Carbamide peroxide (CP) compared with Phenol glycerin (PG) ear drops on cerumen. Materials and

Methods:

This experimental study investigated the effect of PG and CP ear drops on cerumen in ex vivo and in vivo phases. In the ex vivo phase cerumen degredation was scored following PG and CP treatments. In the in vivo phase, 29 patients with bilateral cerumen impaction were randomly entered the study. PG and CP were applied 3 times a day (each time 5 drops) for 4 days by patients. After treatments, the time of cerumen removal was measured.

Results:

Instant changes showing degredation of cerumen (grade 1) was evident when it was exposed to CP, on the other hand degredation changes (grade 1) in cerumen treated with PG was only evident after 20 min incubation at 37 oC, while grade 3 degredation was evident in cerumen treated with CP after the same time incubation. Although the time needed for removal of cerumen was lower in CP treatment (54.10±31.77) compared to PG treatment (67.10±35.54), the difference was not statistically significant.

Conclusion:

Based on the literature and our results, carbamide peroxide is suggested as a proper treatment for patients with EAC obstruction caused by cerumen compaction, because not only it is significantly effective in cerumen degredation, but also no side effects have been reported.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Otorhinolaryngol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Otorhinolaryngol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán