Smartphone-Integrated Wireless Portable Potentiostat to Develop 5th-Generation Dengue Pocket Aptasensor toward Portronicx-Approach.
ACS Appl Bio Mater
; 7(4): 2299-2308, 2024 04 15.
Article
en En
| MEDLINE
| ID: mdl-38476032
ABSTRACT
Smartphones' widespread availability and worldwide connection are advancing the idea of mobile-based healthcare and promise to transform the business of biosensors. Biosensors based on smartphones have been investigated in several ways, including employing a smartphone in place of a detector or as an instrumental interface. The current work demonstrates the first successful detection of dengue virus using a smartphone-based pocket sensor combined with a wireless potentiostat. The platform developed comprises a smartphone, a wireless portable potentiostat, an Android app, and a three-electrode setup. The combination of portable diagnostic with electronic application is referred to as "Portronicx", and this is the first time that the term "Portronicx" has been used in a dengue sensor, so the current study has the potential to be commercialized in the market with the tag line "Portronicx-commercialization" in the future. Miniaturization improves alternative setup options in terms of instrument size, affordability, mobility, touch-mobile display, and design versatility. The current work proved the excellent combination of a wireless potentiostat with an aptasensor to detect dengue antigen within 20 s with good LOD (0.1 µg/mL) and easy to carry in their pockets. The created platform also performed effectively in human serum. This study replaced all of the instruments with a lightweight touch smartphone, paving the way for the production of fifth-generation electrochemical aptasensors, with potential implications for healthcare applications on the verge of commercialization.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Técnicas Biosensibles
/
Dengue
Límite:
Humans
Idioma:
En
Revista:
ACS Appl Bio Mater
Año:
2024
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Estados Unidos