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Structural Elucidation of a Polysaccharide from Flammulina velutipes and Its Lipid-Lowering and Immunomodulation Activities.
Jia, Wei; Wang, Wenhan; Yu, Dongsheng; Yu, Yangchao; Feng, Zhan; Li, Hewen; Zhang, Jingsong; Zhang, Henan.
Afiliación
  • Jia W; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, P. R. China, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungal Processing,
  • Wang W; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, P. R. China, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungal Processing,
  • Yu D; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, P. R. China, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungal Processing,
  • Yu Y; Jiangsu Chinagreen Biotechnology Co., Ltd., Suqian 223700, China.
  • Feng Z; Jiangsu Chinagreen Biotechnology Co., Ltd., Suqian 223700, China.
  • Li H; Jiangsu Chinagreen Biotechnology Co., Ltd., Suqian 223700, China.
  • Zhang J; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, P. R. China, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungal Processing,
  • Zhang H; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, P. R. China, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungal Processing,
Polymers (Basel) ; 16(5)2024 Feb 22.
Article en En | MEDLINE | ID: mdl-38475282
ABSTRACT
FVPT1, a novel heteropolysaccharide, was purified from the fruiting body of Flammulina velutipes using magnetic-field-assisted three-phase partitioning and gel permeation chromatography. The structure was characterized using monosaccharide composition and methylation analysis, infrared spectroscopy and nuclear magnetic resonance (NMR). The FVPT1 (~1.64 × 104 Da) was composed of L-fucose, D-galactose, D-glucose and D-mannose at a molar ratio of 1.03.51.01.4. The polysaccharide repeating unit of FVPT1 was established with methylation analyses and NMR spectroscopy. Moreover, a zebrafish larva hyperlipidemia model test demonstrated that FVPT1 can show appreciable lipid-lowering effects. In addition, the FVPT1 exhibited remarkable immunoregulatory activity by increasing nitric oxide, interleukin (IL)-1ß and IL-1 secretion in macrophages. Therefore, these results suggest that FVPT1 has the potential to be developed into a new immune or hypolipidemic health product.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza