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Ameliorative effect of Ononis natrix against chronic lead poisoning in mice: neurobehavioral, biochemical, and histological study.
Haj-Khlifa, Asmaa; Aziz, Faissal; Tastift, Maroua Ait; Sellami, Souad; Rais, Hanane; Hammoud, Miloud; Fdil, Naima; Kissani, Najib; Gamrani, Halima; Bouyatas, Moulay Mustapha.
Afiliación
  • Haj-Khlifa A; Neuroscience, Pharmacology and Environment Unit (ENPE), Departement of Biology, Faculty of Sciences Semlalia,, Cadi Ayyad University, 40000, Marrakech, Morocco.
  • Aziz F; Laboratory of Clinical and Experimental Neurosciences and Environment, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
  • Tastift MA; Laboratory of Water, Biodiversity, and Climate Change, Faculty of Sciences Semlalia, Cadi Ayyad University, 2390, 40000, Marrakech, BP, Morocco.
  • Sellami S; Laboratory of Agri-Food, Biotechnology, and Valorization of Plant Resources, Phytochemistry and Pharmacology of Medicinal Plants Unit, Faculty of Sciences Semlalia, Cadi Ayyad University, Avenue Prince Moulay Abdellah, 40000, Marrakech, BP 2390, Morocco.
  • Rais H; Mohammed VI University Hospital, Marrakech, Morocco.
  • Hammoud M; Mohammed VI University Hospital, Marrakech, Morocco.
  • Fdil N; Laboratory of Immunohistochemistry, Anatomic Pathology Department, University Hospital Center (CHU) Mohammed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
  • Kissani N; Metabolics Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayyad University, Sidi Abbad, 40000, Marrakech, BP, Morocco.
  • Gamrani H; Metabolics Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayyad University, Sidi Abbad, 40000, Marrakech, BP, Morocco.
  • Bouyatas MM; Laboratory of Clinical and Experimental Neurosciences and Environment, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Biol Trace Elem Res ; 2024 Mar 12.
Article en En | MEDLINE | ID: mdl-38472511
ABSTRACT
Lead (Pb) is one of the most common heavy metals with toxicological effects on many tissues in humans as well as animals. In order to counteract the toxic effects of this metal, the administration of synthetic or natural antioxidants is thus required. The aim of this study was to examine the beneficial effect of the aqueous extract of Ononis natrix (AEON) against lead acetate-induced damage from a behavioral, biochemical, and histological point of view. Forty-eight male mice were divided into four equal groups Ctr (control); Pb (lead acetate 1g/l); Pb + On 100 mg/kg (lead acetate 1 g/l + AEON 100 mg/kg); Pb + On 500 mg/kg (lead acetate 1 g/l + AEON 500 mg/kg). AEON was administered orally from day 21 after the start of lead exposure up to the end of the experiment. The results revealed that lead induced behavioral disorders, increased serum levels of liver markers (AST, ALT, and bilirubin), as well as kidney markers (urea and creatinine). At the same time, levels of thiobarbituric acid reactive substances (TBARS) and glutathione peroxidase (GPx) increased significantly. Moreover, Pb caused structural changes in the liver and kidneys of Pb-exposed mice. However, AEON administration significantly improved all lead-induced brain, liver, and kidney dysfunctions. Our results suggest that AEON could be a source of molecules with therapeutic potential against brain, liver, and kidney abnormalities caused by lead exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Trace Elem Res Año: 2024 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Trace Elem Res Año: 2024 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos