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Laser assisted pulmonary metastasectomy promises a low local recurrence rate.
Shalabi, Ahmad; Ehab, Ahmed; Shalabi, Sundus F; Kugler, Gudrun; Schäfers, H-J; Graeter, Thomas.
Afiliación
  • Shalabi A; Thoracic and Vascular Surgery Department, SLK Lung Medical Center Löwenstein, Löwenstein, Germany. ahmadfshalabi@gmail.com.
  • Ehab A; Pulmonary Medicine Department, SLK Lung Medical Center Löwenstein, Löwenstein, Germany.
  • Shalabi SF; Pulmonary Medicine Department, Mansoura University, Mansoura, Egypt.
  • Kugler G; Faculty of Medicine, Arab American University, Jenin, Palestine.
  • Schäfers HJ; Thoracic and Vascular Surgery Department, SLK Lung Medical Center Löwenstein, Löwenstein, Germany.
  • Graeter T; Cardiovascular and Thoracic Surgery Department, Saarland University Medical Center, Homburg/Saar, Germany.
Sci Rep ; 14(1): 5988, 2024 03 12.
Article en En | MEDLINE | ID: mdl-38472291
ABSTRACT
Pulmonary metastasectomy (PM) is consensually performed in a parenchyma-sparing manner to preserve functionally healthy lung tissue. However, this may increase the risk of local recurrence at the surgical margin. Laser assisted pulmonary metastasectomy (LPM) is a relatively recent innovation that is especially useful to resect multiple metastatic pulmonary nodules. In this study we investigated the rate of local recurrence after LPM and evaluated the influence of various clinical and pathological factors on local recurrence. Retrospectively, a total of 280 metastatic nodules with different histopathological entities were studied LPM from 2010 till 2018. All nodules were resected via diode-pumped neodymium yttrium-aluminum-garnet (NdYAG) 1,318 nm laser maintaining a safety margin of 5 mm. Patients included were observed on average for 44 ± 17 months postoperatively. Local recurrence at the surgical margin following LPM was found in 9 nodules out of 280 nodules (3.21%). Local recurrence at the surgical margin occurred after 20 ± 8.5 months post operation. Incomplete resection (p = < 0.01) and size of the nodule (p = < 0.01) were associated with significantly increased risk of local recurrence at the surgical margin. Histology of the primary disease showed no impact on local recurrence. Three and five-year survival rates were 84% and 49% respectively. Following LPM, the rate of local recurrence is low. This is influenced by the size of the metastatic nodules and completeness of the resection. Obtaining a safety margin of 5 mm seems to be sufficient, larger nodules require larger safety margins.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nódulos Pulmonares Múltiples / Metastasectomía / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nódulos Pulmonares Múltiples / Metastasectomía / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido