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Galectin-3, Metabolic Risk, and Incident Heart Failure: The ARIC Study.
Echouffo-Tcheugui, Justin B; Zhang, Sui; Florido, Roberta; Pankow, James S; Michos, Erin D; Goldberg, Ronald B; Nambi, Vijay; Gerstenblith, Gary; Post, Wendy S; Blumenthal, Roger S; Ballantyne, Christie M; Coresh, Josef; Selvin, Elizabeth; Ndumele, Chiadi E.
Afiliación
  • Echouffo-Tcheugui JB; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine Johns Hopkins University Baltimore MD.
  • Zhang S; Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD United States.
  • Florido R; Division of Cardiology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD.
  • Pankow JS; Department of Epidemiology at the University of Minnesota Minneapolis MN.
  • Michos ED; Division of Cardiology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD.
  • Goldberg RB; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine University of Miami Miami FL.
  • Nambi V; Section of Cardiovascular Research Baylor College of Medicine and Houston Methodist DeBakey Heart and Vascular Center Houston TX.
  • Gerstenblith G; Division of Cardiology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD.
  • Post WS; Division of Cardiology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD.
  • Blumenthal RS; Division of Cardiology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD.
  • Ballantyne CM; Section of Cardiovascular Research Baylor College of Medicine and Houston Methodist DeBakey Heart and Vascular Center Houston TX.
  • Coresh J; Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD United States.
  • Selvin E; Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD United States.
  • Ndumele CE; Division of Cardiology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD.
J Am Heart Assoc ; 13(6): e031607, 2024 Mar 19.
Article en En | MEDLINE | ID: mdl-38471823
ABSTRACT

BACKGROUND:

It is unclear how metabolic syndrome (MetS) and diabetes affect Gal-3 (galectin 3) levels and the resulting implications for heart failure (HF) risk. We assessed relationships of MetS and diabetes with Gal-3, and their joint associations with incident HF. METHODS AND

RESULTS:

We included 8445 participants without HF (mean age, 63 years; 59% men; 16% Black race) at ARIC (Atherosclerosis Risk in Communities) study visit 4 (1996-1999). We categorized participants as having MetS only, MetS with diabetes, or neither, and by quartiles of MetS severity Z score. We assessed cross-sectional associations of metabolic risk categories with high Gal-3 level (≥75th percentile) using logistic regression. We used Cox regression to evaluate combined associations of metabolic risk categories and Gal-3 quartiles with HF. In cross-sectional analyses, compared with no MetS and no diabetes, MetS only (odds ratio [OR], 1.24 [95% CI, 1.10-1.41]) and MetS with diabetes (OR, 1.59 [95% CI, 1.32-1.92]) were associated with elevated Gal-3. Over a median follow-up of 20.5 years, there were 1749 HF events. Compared with individuals with neither diabetes nor MetS and with Gal-3 in the lowest quartile, the combination of MetS with diabetes and Gal-3 ≥75th percentile was associated with a 4-fold higher HF risk (hazard ratio, 4.35 [95% CI, 3.30-5.73]). Gal-3 provided HF prognostic information above and beyond MetS, NT-proBNP (N-terminal pro-B-type natriuretic peptide), high-sensitivity cardiac troponin T, and CRP (C-reactive protein) (ΔC statistic for models with versus without Gal-3 0.003; P=0.004).

CONCLUSIONS:

MetS and diabetes are associated with elevated Gal-3. The HF risk significantly increased with the combination of greater metabolic risk and higher Gal-3.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Insuficiencia Cardíaca Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Insuficiencia Cardíaca Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido