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Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease.
Niu, Zhiqiang; Liu, Yanan; Shen, Ruyi; Jiang, Xiaojian; Wang, Yanting; He, Ziliang; Li, Junyao; Hu, Yeye; Zhang, Ji; Jiang, Yunyao; Hu, Weicheng; Si, Chuanling; Wei, Shuai; Shen, Ting.
Afiliación
  • Niu Z; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Liu Y; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Shen R; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Jiang X; School of Life Sciences, Huaiyin Normal University, Huaian 223300, China.
  • Wang Y; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • He Z; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Li J; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Hu Y; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Zhang J; School of Life Sciences, Huaiyin Normal University, Huaian 223300, China.
  • Jiang Y; Institute for Chinese Materia Medica, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
  • Hu W; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China.
  • Si C; Tianjin Key Laboratory of Pulp & Paper, Tianjin University of Science & Technology, Tianjin, 300457, China. Electronic address: sichli@tust.edu.cn.
  • Wei S; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: weis@gdou.edu.cn.
  • Shen T; Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China. Electronic address: 008348@yzu.edu.cn.
Phytomedicine ; 127: 155474, 2024 May.
Article en En | MEDLINE | ID: mdl-38471369
ABSTRACT

BACKGROUND:

Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestine, which significantly affects patients' quality of life. As a perennial plant with the homology of medicine and food, Panax ginseng is known for its substantial anti-inflammatory effects in various inflammatory disorders. Ginsenosides, the main bioactive compounds of P. ginseng, are recognized for their efficacy in ameliorating inflammation.

PURPOSE:

Over the past decade, approximately 150 studies have investigated the effects of P. ginseng and ginsenosides on IBD treatment and new issues have arisen. However, there has yet to be a comprehensive review assessing the potential roles of ginsenosides in IBD therapy.

METHOD:

This manuscript strictly adheres to the PRISMA guidelines, thereby guaranteeing systematic synthesis of data. The research articles referenced were sourced from major scientific databases, including Google Scholar, PubMed, and Web of Science. The search strategy employed keywords such as "ginsenoside", "IBD", "colitis", "UC", "inflammation", "gut microbiota", and "intestinal barrier". For image creation, Figdraw 2.0 was methodically employed.

RESULTS:

Treatment with various ginsenosides markedly alleviated clinical IBD symptoms. These compounds have been observed to restore intestinal epithelia, modulate cellular immunity, regulate gut microbiota, and suppress inflammatory signaling pathways.

CONCLUSION:

An increasing body of research supports the potential of ginsenosides in treating IBD. Ginsenosides have emerged as promising therapeutic agents for IBD, attributed to their remarkable efficacy, safety, and absence of side effects. Nevertheless, their limited bioavailability presents a substantial challenge. Thus, efforts to enhance the bioavailability of ginsenosides represent a crucial and promising direction for future IBD research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Ginsenósidos / Panax Límite: Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Ginsenósidos / Panax Límite: Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania