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Targeted Testing and Treatment To Reduce Human Malaria Transmission in High-Risk Populations: A Systematic Review.
Bhamani, Beena; Martí Coma-Cros, Elisabet; Tusell, Maria; Mithi, Vita; Serra-Casas, Elisa; Williams, Nana Aba; Lindblade, Kim A; Allen, Koya C.
Afiliación
  • Bhamani B; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
  • Martí Coma-Cros E; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
  • Tusell M; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
  • Mithi V; Armref Data for Action in Public Health Research Consultancy, Mzuzu, Malawi.
  • Serra-Casas E; Society for Research on Nicotine and Tobacco-Genetics and Omics Network, Madison, Wisconsin.
  • Williams NA; Leaders of Africa Institute, Baltimore, Maryland.
  • Lindblade KA; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
  • Allen KC; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Am J Trop Med Hyg ; 110(4_Suppl): 54-64, 2024 Apr 02.
Article en En | MEDLINE | ID: mdl-38471159
ABSTRACT
As countries approach elimination of malaria, groups with increased exposure to malaria vectors or poor access to health services may serve as important human reservoirs of infection that help maintain transmission in the community. Parasitological testing and treatment targeted to these groups may reduce malaria transmission overall. This systematic review assessed the effectiveness of targeted testing and treatment (TTaT) to reduce malaria transmission, the contextual factors, and the results of modeling studies that estimated the intervention's potential impact. Bibliographic searches were conducted in March 2021 and updated in April 2022, and a total of 1,210 articles were identified. Three studies were included for outcome data one factorial cluster randomized controlled trial (cRCT) in Kenya (5,233 participants), one cRCT in Ghana (3,046 participants), and one controlled before-and-after cohort study in schoolchildren in Malawi (786 participants). Nine reports were included for contextual factors, and two were included for mathematical modeling. Data on outcomes from the three studies suggested that at the community level, TTaT would result in little to no difference in the incidence of malaria infection (measured via active surveillance), adverse events, and severe AEs. In contrast, the effects of TTaT on prevalence (malaria parasitemia) among those targeted by the intervention were found to include a short-term impact on reducing transmission but little to no impact on transmission for extended periods. Future iterations of this review should ensure consideration for populations proven to host the vast majority of the reservoir of infection in lower-transmission settings to determine the effectiveness of the intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos