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Asymptomatic Enteric Virus Infections and Association with the Gut Microbiome in Rural Residents of Northern Laos.
Sekiya, Sae; Masuoka, Hiroaki; Mizuno, Yuki; Kibe, Mihoko; Kosaka, Satoko; Natsuhara, Kazumi; Hirayama, Kazuhiro; Inthavong, Nouhak; Kounnavong, Sengchanh; Tomita, Shinsuke; Takayasu, Lena; Suda, Wataru; Yagyu, Fumihiro; Umezaki, Masahiro.
Afiliación
  • Sekiya S; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Masuoka H; Laboratory for Microbiome Science, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Mizuno Y; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kibe M; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kosaka S; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Natsuhara K; Faculty of Nursing, Toho University, Tokyo, Japan.
  • Hirayama K; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
  • Inthavong N; Ministry of Health, Lao Tropical and Public Health Institute, Vientiane, Laos.
  • Kounnavong S; Ministry of Health, Lao Tropical and Public Health Institute, Vientiane, Laos.
  • Tomita S; Graduate School of Environmental Studies, Nagoya University, Nagoya, Japan.
  • Takayasu L; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Suda W; Laboratory for Microbiome Science, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Yagyu F; Graduate School of International Development and Cooperation, Kibi International University, Hyogo, Japan.
  • Umezaki M; Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Am J Trop Med Hyg ; 110(4): 759-767, 2024 Apr 03.
Article en En | MEDLINE | ID: mdl-38471149
ABSTRACT
Viral gastrointestinal infections are an important public health concern, and the occurrence of asymptomatic enteric virus infections makes it difficult to prevent and control their spread. This study aimed to determine the prevalence of and factors associated with asymptomatic enteric virus infection in adults in northern Laos. Fecal samples were collected from apparently healthy participants who did not report diarrhea or high fever at the time of the survey in northern Laos, and enteric viruses were detected using polymerase chain reaction (PCR) and reverse transcription (RT)-PCR. Individual characteristics, including the gut microbiome, were compared between asymptomatic carriers and noncarriers of each enteric virus. Of the participants (N = 255), 12 (4.7%) were positive for norovirus genogroup I (GI), 8 (3.1%) for human adenovirus, and 1 (0.4%) for norovirus GII; prevalence tended to be higher in less-modernized villages. Gut microbial diversity (evaluated by the number of operational taxonomic units) was higher in asymptomatic carriers of norovirus GI or human adenovirus than in their noncarriers. Gut microbiome compositions differed significantly between asymptomatic carriers and noncarriers of norovirus GI or human adenovirus (permutational analysis of variance, P <0.05). These findings imply an association between asymptomatic enteric virus infection and modernization and/or the gut microbiome in northern Laos.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / Infecciones por Caliciviridae / Norovirus / Microbioma Gastrointestinal / Gastroenteritis Límite: Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / Infecciones por Caliciviridae / Norovirus / Microbioma Gastrointestinal / Gastroenteritis Límite: Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos