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Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives.
Vagena, Ioanna-Aglaia; Gatou, Maria-Anna; Theocharous, Giorgos; Pantelis, Pavlos; Gazouli, Maria; Pippa, Natassa; Gorgoulis, Vassilis G; Pavlatou, Evangelia A; Lagopati, Nefeli.
Afiliación
  • Vagena IA; Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Gatou MA; Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15772 Athens, Greece.
  • Theocharous G; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Pantelis P; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Gazouli M; Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Pippa N; School of Science and Technology, Hellenic Open University, 26335 Patra, Greece.
  • Gorgoulis VG; Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National Kapodistrian University of Athens (NKUA), 15771 Athens, Greece.
  • Pavlatou EA; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
  • Lagopati N; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
Nanomaterials (Basel) ; 14(5)2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38470728
ABSTRACT
The wide array of structures and characteristics found in ZnO-based nanostructures offers them a versatile range of uses. Over the past decade, significant attention has been drawn to the possible applications of these materials in the biomedical field, owing to their distinctive electronic, optical, catalytic, and antimicrobial attributes, alongside their exceptional biocompatibility and surface chemistry. With environmental degradation and an aging population contributing to escalating healthcare needs and costs, particularly in developing nations, there's a growing demand for more effective and affordable biomedical devices with innovative functionalities. This review delves into particular essential facets of different synthetic approaches (chemical and green) that contribute to the production of effective multifunctional nano-ZnO particles for biomedical applications. Outlining the conjugation of ZnO nanoparticles highlights the enhancement of biomedical capacity while lowering toxicity. Additionally, recent progress in the study of ZnO-based nano-biomaterials tailored for biomedical purposes is explored, including biosensing, bioimaging, tissue regeneration, drug delivery, as well as vaccines and immunotherapy. The final section focuses on nano-ZnO particles' toxicity mechanism with special emphasis to their neurotoxic potential, as well as the primary toxicity pathways, providing an overall review of the up-to-date development and future perspectives of nano-ZnO particles in the biomedicine field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza