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Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review.
Chancel, R; Lopez-Castroman, J; Baca-Garcia, E; Mateos Alvarez, R; Courtet, Ph; Conejero, I.
Afiliación
  • Chancel R; PSNREC, Univ Montpellier, INSERM, CHU de Montpellier, Montpellier, France.
  • Lopez-Castroman J; Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.
  • Baca-Garcia E; Department of Psychiatry, Nimes University Hospital, Nimes, France.
  • Mateos Alvarez R; Department of Signal Theory and Communications, Carlos III University, Madrid, Spain.
  • Courtet P; Institut de Génomique Fonctionnelle, University of Montpellier, CNRS-INSERM, Montpellier, France.
  • Conejero I; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.
Curr Psychiatry Rep ; 26(3): 78-103, 2024 03.
Article en En | MEDLINE | ID: mdl-38470559
ABSTRACT
PURPOSE OF REVIEW Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and "Aged, 80 and over". Studies were included if they met the following criteria (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers. Reviews, case reports, studies not in English and studies for which no full text was available were excluded. A total of 26 papers were included in the final analysis. RECENT

FINDINGS:

Genomic markers of bipolar disorder in older adults highlighted the implication of serotonin metabolism, while the expression of genes involved in angiogenesis was dysregulated. Peripheral blood markers were mainly related with low grade inflammation, axonal damage, endothelial dysfunction, and the dysregulation of the HPA axis. Neuroanatomical markers reflected a dysfunction of the frontal cortex, a loss of neurones in the anterior cingulate cortex and a reduction of the hippocampal volume (in patients older than 50 years old). While not necessarily limited to older adults, some of them may be useful for differential diagnosis (neurofilaments), disease staging (homocysteine, BDNF) and the monitoring of treatment outcomes (matrix metalloproteinases). Our review provides a comprehensive overview of the current evidence on biomarkers for bipolar disorder in the older adults. The identification of biomarkers may aid in the diagnosis, treatment selection, and monitoring of bipolar disorder in older adults, ultimately leading to improved outcomes for this population. Further research is needed to validate and further explore the potential clinical utility of biomarkers in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar Límite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Curr Psychiatry Rep Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar Límite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Curr Psychiatry Rep Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos