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Reversal of Valproate-Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats.
Cergel, Eda; Tuzuner, Burcin Alev; Turkyilmaz, Ismet Burcu; Oktay, Sehkar; Magaji, Umar Faruk; Sacan, Ozlem; Yanardag, Refiye; Yarat, Aysen.
Afiliación
  • Cergel E; Biochemistry Master of Science Student, Health Sciences Institute, Marmara University, Maltepe, Istanbul, Turkiye.
  • Tuzuner BA; Department of Nutrition and Dietetics, Faculty of Health Sciences, Halic University, Eyupsultan, Istanbul, Turkiye.
  • Turkyilmaz IB; Department of Biochemistry, Faculty of Dentistry, Istanbul Gelisim University, Avcilar, Istanbul, Turkiye.
  • Oktay S; Life Sciences and Biomedical Engineering Application and Research Centre, Istanbul Gelisim University, Avcilar, Istanbul, Turkiye.
  • Magaji UF; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkiye.
  • Sacan O; Department of Basic Medical Sciences, Biochemistry, Faculty of Dentistry, Marmara University, Maltepe, Istanbul, Turkiye.
  • Yanardag R; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkiye.
  • Yarat A; Department of Biochemistry and Molecular Biology, Federal University Birnin Kebbi, Birnin Kebbi, Kebbi State, Nigeria.
Chem Biodivers ; 21(5): e202301959, 2024 May.
Article en En | MEDLINE | ID: mdl-38469951
ABSTRACT
This study aimed to explore the potential protective impacts of Moringa oleifera extract on major alteration in salivary glands of rats exposed to sodium valproate (VA). Groups were defined as control, control+moringa extract, sodium valproate, and sodium valproate+moringa extract. Antioxidant and oxidant status, activities of digestive and metabolic enzymes were examined. VA treatment led to various biochemical changes in the salivary glands, including decreased levels of antioxidants like glutathione, glutathione-S-transferase, and superoxide dismutase (except for sublingual superoxide dismutase). Conversely, a decrease in alpha-amylase, alkaline and acid phosphatase, lactate dehydrogenase, protease, and maltase activities were observed. The study also demonstrated that VA induces oxidative stress, increases lipid peroxidation, sialic acid, and nitric oxide levels in the salivary glands. Total oxidant capacity was raised in all glands except in the sublingual gland. The electrophoretic patterns of proteins were similar. Moringa oleifera extract exhibited protective properties, reversing these VA-induced biochemical changes due to its antioxidant and therapeutic attributes. This research suggests that moringa extract might serve as an alternative treatment approach for individuals using VA and experiencing salivary gland issues, although further research is necessary to confirm these findings in human subjects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Extractos Vegetales / Ácido Valproico / Moringa oleifera / Antioxidantes Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Extractos Vegetales / Ácido Valproico / Moringa oleifera / Antioxidantes Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza