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Baseline levels of circulating galectin-1 associated with radiographic hand but not radiographic knee osteoarthritis at a two-year follow-up.
Andersson, M L E; Zimmerman, M; Brogren, E; Bergman, S; Strindberg, L; Fryk, E; Jansson, P A.
Afiliación
  • Andersson MLE; Spenshult Research and Development Center, Halmstad, Sweden.
  • Zimmerman M; Department of Environmental and Biosciences, School of Business, Innovation and Sustainability, Halmstad University, Halmstad, Sweden.
  • Brogren E; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden.
  • Bergman S; Department of Orthopaedics, Helsingborg Hospital, Helsingborg, Sweden.
  • Strindberg L; Department of Translational Medicine - Hand Surgery, Lund University, Lund, Sweden.
  • Fryk E; Department of Translational Medicine - Hand Surgery, Lund University, Lund, Sweden.
  • Jansson PA; Department of Hand Surgery, Skåne University Hospital, Malmö, Sweden.
Osteoarthr Cartil Open ; 6(2): 100455, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38469554
ABSTRACT

Objective:

We tested the potential of circulating galectin-1, interleukin (IL)-1 beta, IL-6, and tumour necrosis factor alpha (TNF alpha) levels at baseline in individuals with knee pain as biomarkers for development of radiographic knee and/or hand osteoarthritis (OA).

Design:

This study comprised 212 individuals with knee pain from the Halland osteoarthritis cohort (HALLOA). Clinical characteristics and serum/plasma levels of galectin-1, IL-1 beta, IL-6, and TNF alpha were measured at baseline, and knee and hand radiographs were obtained at a two-year follow-up. The predictive value of circulating inflammatory markers and clinical variables at baseline was assessed using multinominal logistic regression for those who developed radiographic OA in knees only (n â€‹= â€‹25), in hands only (n â€‹= â€‹40), and in both knees and hands (n â€‹= â€‹43); the group who did not develop OA (n â€‹= â€‹104) was used as reference. Correlations were assessed using Spearman's correlation coefficients.

Results:

As expected, age was identified as a risk factor for having radiographic knee and/or hand OA at the two-year follow-up. Baseline circulating galectin-1 levels did not associate with developing radiographic knee OA but associated with developing radiographic hand OA (odds ratio (OR) for a 20% increased risk 1.14, 95% confidence interval (CI) 1.01-1.29) and both radiographic knee and hand OA (OR for a 20% increased risk 1.18, 95% CI 1.05-1.30). However, baseline IL-1 beta, IL-6, and TNF alpha did not associate with developing radiographic knee and/or hand OA.

Conclusion:

Non-age adjusted circulating galectin-1 is superior to IL-6, IL-1 beta, and TNF alpha in predicting radiographic hand but not knee OA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Osteoarthr Cartil Open Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Osteoarthr Cartil Open Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido