Your browser doesn't support javascript.
loading
Urtica pilulifera leaves extract mitigates cadmium induced hepatotoxicity via modulation of antioxidants, inflammatory markers and Nrf-2 signaling in mice.
Hussein, Shaimaa; Ben Bacha, Abir; Alonazi, Mona; Alwaili, Maha Abdullah; Mobasher, Maysa A; Alburae, Najla Ali; Banjabi, Abeer A; El-Said, Karim Samy.
Afiliación
  • Hussein S; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al Jawf, Saudi Arabia.
  • Ben Bacha A; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
  • Alonazi M; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
  • Alwaili MA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Mobasher MA; Department of Pathology, Biochemistry Division, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
  • Alburae NA; Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Banjabi AA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • El-Said KS; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
Front Mol Biosci ; 11: 1365440, 2024.
Article en En | MEDLINE | ID: mdl-38469182
ABSTRACT

Introduction:

Cadmium (Cd) is a harmful heavy metal that results in many toxic issues. Urtica pilulifera showed potential pharmaceutical applications. This study investigated the possible ameliorative mechanism of Urtica pilulifera leaves extract (UPLE) against hepatotoxicity induced by cadmium chloride (CdCl2) in mice.

Methods:

In vitro phytochemical screening and the metal-chelating activity of UPLE were ascertained. Four groups of forty male mice were used (n = 10) as follows; Group 1 (G1) was a negative control. G2 was injected i.p., with UPLE (100 mg/kg b. wt) daily. G3 was injected i.p., with Cd (5 mg/kg b. wt) daily. G4 was injected with Cd as in G3 and with UPLE as in G2. On day 11, the body weight changes were evaluated, blood, and serum samples were collected for hematological and biochemical assessments. Liver tissues were used for biochemical, molecular, and histopathological investigations.

Results:

The results showed that UPLE contains promising secondary metabolites that considerably lessen the negative effects of Cd on liver. Furthermore, UPLE inhibited oxidative stress and inflammation; restored antioxidant molecules; and promoted nuclear-related factor-2 (Nrf-2) expression. Also, UPLE improved the histopathological alterations induced by Cd.

Discussion:

This study explored the beneficial role of UPLE treatment in Cd-induced liver injury through enhancing Nrf-2 signaling and antioxidant enzyme gene expression in the liver of mice. Therefore, UPLE could have valuable implications against hepatotoxicity induced by environmental cadmium exposure. Which can be used as a chelating agent against Cd.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Mol Biosci Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Mol Biosci Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza