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Circulating markers of oxidative stress and risk of incident cardiovascular events in obstructive sleep apnea.
Allen, A J Hirsch; Peres, Bernardo U; Liu, Yu; Jen, Rachel; Shah, Aditi; Laher, Ismail; Almeida, Fernanda; Taylor, Carolyn; Ghafoor, Ali Abdul; Ayas, Najib T.
Afiliación
  • Allen AJH; Department of Medicine, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, 7th Floor, Vancouver, BC V5Z 1M9 Canada.
  • Peres BU; Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
  • Liu Y; Department of Medicine, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, 7th Floor, Vancouver, BC V5Z 1M9 Canada.
  • Jen R; Department of Pharmacology, Shanxi Medical University, Taiyuan, China.
  • Shah A; Department of Medicine, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, 7th Floor, Vancouver, BC V5Z 1M9 Canada.
  • Laher I; Leon Judah Blackmore Sleep Disorders Program, UBC Hospital, Vancouver, Canada.
  • Almeida F; Department of Medicine, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, 7th Floor, Vancouver, BC V5Z 1M9 Canada.
  • Taylor C; Leon Judah Blackmore Sleep Disorders Program, UBC Hospital, Vancouver, Canada.
  • Ghafoor AA; Department of Medicine, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, 7th Floor, Vancouver, BC V5Z 1M9 Canada.
  • Ayas NT; Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Sleep Biol Rhythms ; 20(4): 533-540, 2022 Oct.
Article en En | MEDLINE | ID: mdl-38468626
ABSTRACT
The identification of which patients with obstructive sleep apnea (OSA) are more likely to develop cardiovascular disease (CVD) remains a challenge. OSA causes oxidative stress (OS) which may contribute to CVD pathogenesis. Therefore, OS markers could be useful in risk-stratifying cardiovascular (CV) risk in OSA patients. The purpose of this pilot study was to assess whether three OS marker levels could be associated with incident CVD in suspected OSA patients. Morning plasma levels of 8-isoprostane, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and superoxide dismutase (SOD) were measured in patients with suspected OSA referred for a polysomnogram (PSG). A composite outcome of CV events was defined by linkage with provincial administrative health databases. Cox proportional hazards models were used to assess the relationship between the levels of OS markers and events. 352 patients were included (mean age of 51.4 years, 68% male, median apnea hypopnea index of 16/h). Thirty-one first CV events occurred over an 8-year follow-up. In univariate or fully adjusted models, none of the OS markers were significantly associated with incident CV events (hazard ratio in adjusted models of 1.25 (95% CI 0.56-2.80, p = 0.59), 1.15 (0.52-2.57, p = 0.73), 0.77 (0.37-1.61, p = 0.48), for 8-OHdG, 8-isoprostane and SOD; however, confidence intervals were wide. In this small preliminary study, oxidative stress markers were not significantly associated with risk of CV events. However, moderate associations between these markers and risk of CV events are possible and should be the focus of future larger studies. Supplementary Information The online version contains supplementary material available at 10.1007/s41105-022-00399-0.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sleep Biol Rhythms Año: 2022 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sleep Biol Rhythms Año: 2022 Tipo del documento: Article Pais de publicación: Japón