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Downregulation of UBB potentiates SP1/VEGFA-dependent angiogenesis in clear cell renal cell carcinoma.
Wang, Jinpeng; Zhao, Enyang; Geng, Bo; Zhang, Wei; Li, Zhuolun; Liu, Qing; Liu, Weiyang; Zhang, Wenfu; Hou, Wenbin; Zhang, Nan; Liu, Zhiming; You, Bosen; Wu, Pengfei; Li, Xuedong.
Afiliación
  • Wang J; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Zhao E; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Geng B; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Zhang W; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Li Z; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Liu Q; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Liu W; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Zhang W; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Hou W; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Zhang N; Department of Radiation Oncology, Urology, and Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Liu Z; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • You B; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Wu P; Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
  • Li X; Future Medical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Oncogene ; 43(18): 1386-1396, 2024 May.
Article en En | MEDLINE | ID: mdl-38467852
ABSTRACT
Clear cell renal cell carcinoma (ccRCC) presents a unique profile characterized by high levels of angiogenesis and robust vascularization. Understanding the underlying mechanisms driving this heterogeneity is essential for developing effective therapeutic strategies. This study revealed that ubiquitin B (UBB) is downregulated in ccRCC, which adversely affects the survival of ccRCC patients. UBB exerts regulatory control over vascular endothelial growth factor A (VEGFA) by directly interacting with specificity protein 1 (SP1), consequently exerting significant influence on angiogenic processes. Subsequently, we validated that DNA methyltransferase 3 alpha (DNMT3A) is located in the promoter of UBB to epigenetically inhibit UBB transcription. Additionally, we found that an unharmonious UBB/VEGFA ratio mediates pazopanib resistance in ccRCC. These findings underscore the critical involvement of UBB in antiangiogenic therapy and unveil a novel therapeutic strategy for ccRCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Ubiquitina / Neoplasias Renales / Neovascularización Patológica Límite: Animals / Female / Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Ubiquitina / Neoplasias Renales / Neovascularización Patológica Límite: Animals / Female / Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido