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Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.
Summa, K C; Jiang, P; González-Rodríguez, P; Huang, X; Lin, X; Vitaterna, M H; Dan, Y; Surmeier, D J; Turek, F W.
Afiliación
  • Summa KC; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ksumma@northwestern.edu.
  • Jiang P; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA. ksumma@northwestern.edu.
  • González-Rodríguez P; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA.
  • Huang X; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA.
  • Lin X; Neuroscience Discovery, Informatics and Predictive Sciences, Bristol Myers Squibb, Cambridge, MA, USA.
  • Vitaterna MH; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Dan Y; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and CIBERNED, Seville, Spain.
  • Surmeier DJ; Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA.
  • Turek FW; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA.
NPJ Parkinsons Dis ; 10(1): 54, 2024 Mar 11.
Article en En | MEDLINE | ID: mdl-38467673
ABSTRACT
Disrupted sleep has a profound adverse impact on lives of Parkinson's disease (PD) patients and their caregivers. Sleep disturbances are exceedingly common in PD, with substantial heterogeneity in type, timing, and severity. Among the most common sleep-related symptoms reported by PD patients are insomnia, excessive daytime sleepiness, and sleep fragmentation, characterized by interruptions and decreased continuity of sleep. Alterations in brain wave activity, as measured on the electroencephalogram (EEG), also occur in PD, with changes in the pattern and relative contributions of different frequency bands of the EEG spectrum to overall EEG activity in different vigilance states consistently observed. The mechanisms underlying these PD-associated sleep-wake abnormalities are poorly understood, and they are ineffectively treated by conventional PD therapies. To help fill this gap in knowledge, a new progressive model of PD - the MCI-Park mouse - was studied. Near the transition to the parkinsonian state, these mice exhibited significantly altered sleep-wake regulation, including increased wakefulness, decreased non-rapid eye movement (NREM) sleep, increased sleep fragmentation, reduced rapid eye movement (REM) sleep, and altered EEG activity patterns. These sleep-wake abnormalities resemble those identified in PD patients. Thus, this model may help elucidate the circuit mechanisms underlying sleep disruption in PD and identify targets for novel therapeutic approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Parkinsons Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Parkinsons Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos