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Amplification of Mutant NRAS in Melanocytic Tumors With Features of Spitz Tumors.
Cloutier, Jeffrey M; Wang, Meng; Vemula, Swapna S; Mirza, Sonia; Weier, Jingly; Aquino, Jamie D; McCalmont, Timothy H; LeBoit, Philip E; Bastian, Boris C; Yeh, Iwei.
Afiliación
  • Cloutier JM; Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Electronic address: Jeffrey.Cloutier@dartmouth.edu.
  • Wang M; Department of Dermatology, University of California, San Francisco, California.
  • Vemula SS; Department of Dermatology, University of California, San Francisco, California.
  • Mirza S; Department of Dermatology, University of California, San Francisco, California.
  • Weier J; Department of Dermatology, University of California, San Francisco, California.
  • Aquino JD; Department of Pathology, University of California, San Francisco, California.
  • McCalmont TH; Department of Dermatology, University of California, San Francisco, California; Department of Pathology, University of California, San Francisco, California; Golden State Dermatology Associates, Walnut Creek, California.
  • LeBoit PE; Department of Dermatology, University of California, San Francisco, California; Department of Pathology, University of California, San Francisco, California; Helen Diller Family Cancer Center, University of California, San Francisco, California.
  • Bastian BC; Department of Dermatology, University of California, San Francisco, California; Department of Pathology, University of California, San Francisco, California; Helen Diller Family Cancer Center, University of California, San Francisco, California.
  • Yeh I; Department of Dermatology, University of California, San Francisco, California; Department of Pathology, University of California, San Francisco, California; Helen Diller Family Cancer Center, University of California, San Francisco, California. Electronic address: iwei.yeh@ucsf.edu.
Mod Pathol ; 37(5): 100469, 2024 May.
Article en En | MEDLINE | ID: mdl-38467248
ABSTRACT
NRAS activating mutations are prevalent in melanocytic neoplasia, occurring in a subset of common acquired melanocytic nevi and ∼30% of cutaneous melanomas. In this study, we described a cohort of 7 distinctive melanocytic tumors characterized by activating point mutations in codon 61 of NRAS with amplification of the mutant NRAS allele and shared clinicopathologic features. These tumors occurred predominantly in younger patients, with a median age of 20 years (range, 6-56 years). They presented as papules on the helix of the ear (4 cases) or extremities (3 cases). Microscopically, the tumors were cellular, relatively well-circumscribed, compound, or intradermal proliferations. The tumor cells often extended into the deep reticular dermis and involved the superficial subcutaneous fat in some cases. The melanocytes were epithelioid to spindled with moderate amounts of cytoplasm and conspicuous nucleoli. They were arranged in short plexiform fascicles, nests, and cords. Some cases had occasional pleomorphic and multinucleated melanocytes. Rare dermal mitotic figures were present in all cases. The dermis contained thick collagen bundles and minimal solar elastosis. Follow-up data were available for 5 patients, with a median period of 4.2 years (range, 1-9 years), during which no recurrences or metastases were reported. Our series highlights a clinicopathologically and molecularly distinctive subset of NRAS-mutated tumors with amplification of the mutant NRAS allele.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Nevo de Células Epitelioides y Fusiformes / GTP Fosfohidrolasas / Proteínas de la Membrana Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Mod Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Nevo de Células Epitelioides y Fusiformes / GTP Fosfohidrolasas / Proteínas de la Membrana Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Mod Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos