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Volatilomic profiles of gastric juice in gastric cancer patients.
Mezmale, Linda; Slefarska-Wolak, Daria; Bhandari, Manohar Prasad; Ager, Clemens; Veliks, Viktors; Patsko, Veronika; Lukashenko, Andrii; Dias-Neto, Emmanuel; Nunes, Diana Noronha; Bartelli, Thais Fernanda; Pelosof, Adriane Graicer; Sztokfisz, Claudia Zitron; Murillo, Raúl; Królicka, Agnieszka; Mayhew, Chris A; Leja, Marcis; Haick, Hossam; Mochalski, Pawel.
Afiliación
  • Mezmale L; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia.
  • Slefarska-Wolak D; Riga East University Hospital, Riga, Latvia.
  • Bhandari MP; Riga Stradins University, LV-1007, Riga, Latvia.
  • Ager C; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria.
  • Veliks V; Institute of Chemistry, Jan Kochanowski University of Kielce, Kielce, Poland.
  • Patsko V; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia.
  • Lukashenko A; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria.
  • Dias-Neto E; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia.
  • Nunes DN; National Cancer Institute of Ukraine, Kyiv, Ukraine.
  • Bartelli TF; National Cancer Institute of Ukraine, Kyiv, Ukraine.
  • Pelosof AG; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Sztokfisz CZ; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Murillo R; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Królicka A; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Mayhew CA; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Leja M; University Hospital San Ignacio, Bogotá, Colombia.
  • Haick H; Department of Building Materials Technology, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, Krakow, Poland.
  • Mochalski P; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria.
J Breath Res ; 18(2)2024 03 21.
Article en En | MEDLINE | ID: mdl-38467063
ABSTRACT
Volatilomics is a powerful tool capable of providing novel biomarkers for the diagnosis of gastric cancer. The main objective of this study was to characterize the volatilomic signatures of gastric juice in order to identify potential alterations induced by gastric cancer. Gas chromatography with mass spectrometric detection, coupled with headspace solid phase microextraction as the pre-concentration technique, was used to identify volatile organic compounds (VOCs) released by gastric juice samples collected from 78 gastric cancer patients and two cohorts of controls (80 and 96 subjects) from four different locations (Latvia, Ukraine, Brazil, and Colombia). 1440 distinct compounds were identified in samples obtained from patients and 1422 in samples provided by controls. However, only 6% of the VOCs exhibited an incidence higher than 20%. Amongst the volatiles emitted, 18 showed differences in their headspace concentrations above gastric juice of cancer patients and controls. Ten of these (1-propanol, 2,3-butanedione, 2-pentanone, benzeneacetaldehyde, 3-methylbutanal, butylated hydroxytoluene, 2-pentyl-furan, 2-ethylhexanal, 2-methylpropanal and phenol) appeared at significantly higher levels in the headspace of the gastric juice samples obtained from patients; whereas, eight species showed lower abundance in patients than found in controls. Given that the difference in the volatilomic signatures can be explained by cancer-related changes in the activity of certain enzymes or pathways, the former set can be considered potential biomarkers for gastric cancer, which may assist in developing non-invasive breath tests for the diagnosis of this disease. Further studies are required to elucidate further the mechanisms that underlie the changes in the volatilomic profile as a result of gastric cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Compuestos Orgánicos Volátiles Límite: Humans Idioma: En Revista: J Breath Res Año: 2024 Tipo del documento: Article País de afiliación: Letonia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Compuestos Orgánicos Volátiles Límite: Humans Idioma: En Revista: J Breath Res Año: 2024 Tipo del documento: Article País de afiliación: Letonia Pais de publicación: Reino Unido