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A meta­ and bioinformatics analysis of maspin expression levels influencing the prognosis of patients with breast cancer.
Shi, Shuai; Zhang, Zhi-Gang; Sang, Yin-Zhou; Sun, Jie; Ma, Hong-Yan.
Afiliación
  • Shi S; Department of Pathology, Cangzhou People's Hospital, Cangzhou, Hebei 061000, P.R. China.
  • Zhang ZG; Department of Pathology, Cangzhou People's Hospital, Cangzhou, Hebei 061000, P.R. China.
  • Sang YZ; Department of Pathology, Cangzhou People's Hospital, Cangzhou, Hebei 061000, P.R. China.
  • Sun J; Department of Pathology, Cangzhou People's Hospital, Cangzhou, Hebei 061000, P.R. China.
  • Ma HY; Department of Pathology, Cangzhou People's Hospital, Cangzhou, Hebei 061000, P.R. China.
Oncol Lett ; 27(4): 173, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38464336
ABSTRACT
Maspin is a serine protease inhibitor that is encoded by the human SERPINB5 gene. As a tumor inhibitor, it can inhibit the growth of tumor cells, increase adhesion between tumor cells and inhibit tumor angiogenesis. In the present study, a meta- and bioinformatics analysis was performed through the PubMed and China National Knowledge Infrastructure databases including entries added until up to March 20, 2023. It was found that compared with normal breast tissue, maspin expression was downregulated in breast cancer tissue. Maspin expression was negatively associated with lymph node metastasis. According to Kaplan-Meier plotter, it was found that lower maspin expression was negatively associated with the overall and distant metastasis-free survival rate of patients with estrogen receptor-positive, luminal A and grade 2 breast cancer. High expression of maspin was also positively associated with the relapse-free survival rate of patients of the luminal A subtype. Low maspin expression was positively associated with the post-progression and distant metastasis-free survival rate of the progesterone receptor-negative subtype. According to the GEPIA database, SERPINB5 mRNA expression was higher in normal than breast cancer tissues and negatively correlated with the TNM stage. High expression of maspin was also positively associated with the overall survival rate. In the UALCAN database, it was found that the mRNA and promoter methylation levels of SERPINB5 were higher in normal than in breast cancer tissues. These findings suggest that the expression of maspin may serve as a potential marker to indicate the occurrence, subsequent progression and even prognosis of breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Grecia