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A Perspective on Electrical Stimulation and Sympathetic Regeneration in Peripheral Nerve Injuries.
Tian, Tina; Moore, Amy M; Ghareeb, Paul A; Boulis, Nicholas M; Ward, Patricia J.
Afiliación
  • Tian T; Medical Scientist Training Program, Emory University, Atlanta, Georgia, USA.
  • Moore AM; Neuroscience Graduate Program, Laney Graduate School, Emory University, Atlanta, Georgia, USA.
  • Ghareeb PA; Department of Cell Biology, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Boulis NM; Department of Plastic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Ward PJ; Division of Plastic Surgery, Department of Surgery, Emory University, Atlanta, Georgia, USA.
Neurotrauma Rep ; 5(1): 172-180, 2024.
Article en En | MEDLINE | ID: mdl-38463421
ABSTRACT
Peripheral nerve injuries (PNIs) are common and devastating. The current standard of care relies on the slow and inefficient process of nerve regeneration after surgical intervention. Electrical stimulation (ES) has been shown to both experimentally and clinically result in improved regeneration and functional recovery after PNI for motor and sensory neurons; however, its effects on sympathetic regeneration have never been studied. Sympathetic neurons are responsible for a myriad of homeostatic processes that include, but are not limited to, blood pressure, immune response, sweating, and the structural integrity of the neuromuscular junction. Almost one quarter of the axons in the sciatic nerve are from sympathetic neurons, and their importance in bodily homeostasis and the pathogenesis of neuropathic pain should not be underestimated. Therefore, as ES continues to make its way into patient care, it is not only important to understand its impact on all neuron subtypes, but also to ensure that potential adverse effects are minimized. This piece gives an overview of the effects of ES in animals models and in humans while offering a perspective on the potential effects of ES on sympathetic axon regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurotrauma Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurotrauma Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos