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Efficacy of metamizole to prevent kidney injury after renal-ischaemic reperfusion injury in Wistar rats.
Kadar, Dhirajaya Dharma; Warli, Syah Mirsya; Ritarwan, Kiking; Ichwan, Muhammad; Ismi, Jufriady; Fikri, Erjan; Harahap, Juliandi; Alferraly, Ibnu.
Afiliación
  • Kadar DD; Division of Urology.
  • Warli SM; Division of Urology.
  • Ritarwan K; Department of Urology, Universitas Sumatera Utara Hospital, Universitas Sumatera Utara.
  • Ichwan M; Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara-Haji Adam Malik General Hospital.
  • Ismi J; Departments of Pharmacology and Therapeutics.
  • Fikri E; Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala-Zainoel Abidin General Hospital, Banda Aceh, Indonesia.
  • Harahap J; Division of Pediatric Surgery, Department of Surgery.
  • Alferraly I; Public Health.
Ann Med Surg (Lond) ; 86(3): 1408-1415, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38463114
ABSTRACT

Background:

Renal ischaemia-reperfusion injury (RIRI) is a common kidney procedure complication due to temporary blood flow interruption, leading to kidney injuries. This study aimed to analyze the effect of metamizole on the levels of interleukin-18 (IL-18), neutrophil-gelatinase-associated lipocalin (NGAL), myeloperoxidase (MPO), and histopathological changes in rats with RIRI. Materials and

methods:

Animal pre-clinical design study was used. Thirty-two male Wistar rats (Rattus norvegicus) were divided into four groups negative control, positive control, M100, and M200. Blood samples were collected by intracardiac puncture, followed by bilateral nephrectomy and analyzed histopathologically.

Results:

Significant difference in IL-18 levels between positive control vs negative control (114.1 + 12.07 vs. 94.0 + 11.4; P = 0.019) and positive control vs M100 (114.1 + 12.07 vs. 86.9 + 8.34; P = 0.007). There was no difference in NGAL. M100 group had the lowest serum MPO levels (14.78+2.01), there was a significant difference in MPO levels in all pairwise analyses. There was a difference in cumulative EGTI scores among the study groups [positive 10.5 (8-11) vs. negative 9 (7-10) vs. M100 9 (7-10) vs. M200 9 (7-11); P = 0.021].

Conclusion:

Metamizole 100 mg/kgBW can reduce IL-18 and MPO levels in RIRI, giving more optimal results without affecting NGAL levels. Metamizole administration can reduce cumulative EGTI scores in RIRI, both at doses of 100 mg/kgBW and 200 mg/kgBW. This study shows that Metamizole can be used to prevent kidney injury caused by RIRI. IL-18 and MPO can be biomarkers in predicting kidney injury in RIRI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Med Surg (Lond) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Med Surg (Lond) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido