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Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net.
Seadler, Benjamin D; Joyce, David L; Zelten, James; Sweeney, Kevin; Wisgerhof, Taylor; Slettehaugh, Zoey; Yuan, Y William; Tefft, Brandon J; Pearson, Paul J.
Afiliación
  • Seadler BD; Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Joyce DL; Eastern Idaho Regional Medical Center, ID, USA.
  • Zelten J; Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Sweeney K; Resolution Medical, Minneapolis, MN, USA.
  • Wisgerhof T; Resolution Medical, Minneapolis, MN, USA.
  • Slettehaugh Z; Resolution Medical, Minneapolis, MN, USA.
  • Yuan YW; Department of Biomedical Engineering, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Tefft BJ; Department of Biomedical Engineering, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Pearson PJ; Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
Innovations (Phila) ; 19(2): 156-160, 2024.
Article en En | MEDLINE | ID: mdl-38462836
ABSTRACT

OBJECTIVE:

Here we report our preclinical, proof-of-concept testing to assess the ability of a novel device to correct mitral regurgitation. The Milwaukee Heart device aims to enable any cardiac surgeon to perform high-quality mitral valve repair using a standard annuloplasty ring with a crosshatch of microporous, monofilament suture.

METHODS:

Hemodynamic, echocardiographic, and videographic data were collected at baseline, following induction of mitral regurgitation, and after repair using porcine hearts in an ex vivo biosimulator model. A commercially available cardiac prosthesis assessment platform was then used to assess the hydrodynamic characteristics of the study device.

RESULTS:

Porcine biosimulator pressure and flow metrics exhibited successful correction of mitral regurgitation following device implantation with similar values to baseline. Hydrodynamic results yielded pressure gradients and an effective orifice area comparable to currently approved prostheses.

CONCLUSIONS:

The study device effectively reduced mitral valve regurgitation and improved hemodynamics in our preclinical model with similar biophysical metrics to currently approved devices. Future in vivo trials are needed to evaluate the efficacy, biocompatibility, and freedom from the most likely adverse events, such as device thrombosis, embolic events, and hemolysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Valvulares Cardíacas / Anuloplastia de la Válvula Mitral / Prueba de Estudio Conceptual / Hemodinámica / Insuficiencia de la Válvula Mitral Límite: Animals Idioma: En Revista: Innovations (Phila) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Valvulares Cardíacas / Anuloplastia de la Válvula Mitral / Prueba de Estudio Conceptual / Hemodinámica / Insuficiencia de la Válvula Mitral Límite: Animals Idioma: En Revista: Innovations (Phila) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos